Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Katalinic, M.; Rusak, G.; Domacinovic Barovic, J.; Sinko, G.; Jelic, D.; Antolovic, R.; Kovarik, Z.
    Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase (2010), Eur. J. Med. Chem., 45, 186-192.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.8 apigenin
-
Homo sapiens
3.1.1.8 fisetin
-
Homo sapiens
3.1.1.8 galangin
-
Homo sapiens
3.1.1.8 kaempferol
-
Homo sapiens
3.1.1.8 luteolin
-
Homo sapiens
3.1.1.8 additional information docking study show that flavonoids bind to the BChE active site by forming multiple hydrogen bonds and pi-pi interactions Homo sapiens
3.1.1.8 myricetin
-
Homo sapiens
3.1.1.8 quercetin
-
Homo sapiens
3.1.1.8 rutin
-
Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.8 Homo sapiens P06276
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.8 plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.8 propionylthiocholine + H2O
-
Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.8 BChE
-
Homo sapiens
3.1.1.8 butyrylcholinesterase
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.8 25
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.8 7.4
-
assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.1.8 0.0069
-
galangin
-
Homo sapiens
3.1.1.8 0.0374
-
apigenin
-
Homo sapiens
3.1.1.8 0.043
-
kaempferol
-
Homo sapiens
3.1.1.8 0.068
-
quercetin
-
Homo sapiens
3.1.1.8 0.071
-
myricetin
-
Homo sapiens
3.1.1.8 0.09
-
fisetin
-
Homo sapiens
3.1.1.8 0.166
-
luteolin
-
Homo sapiens
3.1.1.8 0.5
-
rutin
-
Homo sapiens