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Literature summary extracted from

  • Lovering, A.L.; Gretes, M.; Strynadka, N.C.
    Structural details of the glycosyltransferase step of peptidoglycan assembly (2008), Curr. Opin. Struct. Biol., 18, 534-543.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.129 RodA RodA is required for isoform PBP2 activity Escherichia coli

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.1.129
-
 Staphylococcus aureus
2.4.1.129
-
 Escherichia coli
2.4.1.129
-
 Aquifex aeolicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.129 AC326-alpha
-
 Aquifex aeolicus
2.4.1.129 AC326-alpha
-
 Bacillus subtilis
2.4.1.129 AC326-alpha
-
 Caulobacter vibrioides
2.4.1.129 AC326-alpha
-
 Cereibacter sphaeroides
2.4.1.129 AC326-alpha
-
 Escherichia coli
2.4.1.129 AC326-alpha
-
 Mycobacterium tuberculosis
2.4.1.129 AC326-alpha
-
 Staphylococcus aureus
2.4.1.129 ACL19273
-
 Aquifex aeolicus
2.4.1.129 ACL19273
-
 Bacillus subtilis
2.4.1.129 ACL19273
-
 Caulobacter vibrioides
2.4.1.129 ACL19273
-
 Cereibacter sphaeroides
2.4.1.129 ACL19273
-
 Escherichia coli
2.4.1.129 ACL19273
-
 Mycobacterium tuberculosis
2.4.1.129 ACL19273
-
 Staphylococcus aureus
2.4.1.129 Garneau-5
-
 Aquifex aeolicus
2.4.1.129 Garneau-5
-
 Bacillus subtilis
2.4.1.129 Garneau-5
-
 Caulobacter vibrioides
2.4.1.129 Garneau-5
-
 Cereibacter sphaeroides
2.4.1.129 Garneau-5
-
 Escherichia coli
2.4.1.129 Garneau-5
-
 Mycobacterium tuberculosis
2.4.1.129 Garneau-5
-
 Staphylococcus aureus
2.4.1.129 HTS6
-
 Aquifex aeolicus
2.4.1.129 HTS6
-
 Bacillus subtilis
2.4.1.129 HTS6
-
 Caulobacter vibrioides
2.4.1.129 HTS6
-
 Cereibacter sphaeroides
2.4.1.129 HTS6
-
 Escherichia coli
2.4.1.129 HTS6
-
 Mycobacterium tuberculosis
2.4.1.129 HTS6
-
 Staphylococcus aureus
2.4.1.129 HTS7
-
 Aquifex aeolicus
2.4.1.129 HTS7
-
 Bacillus subtilis
2.4.1.129 HTS7
-
 Caulobacter vibrioides
2.4.1.129 HTS7
-
 Cereibacter sphaeroides
2.4.1.129 HTS7
-
 Escherichia coli
2.4.1.129 HTS7
-
 Mycobacterium tuberculosis
2.4.1.129 HTS7
-
 Staphylococcus aureus
2.4.1.129 HTS8
-
 Aquifex aeolicus
2.4.1.129 HTS8
-
 Bacillus subtilis
2.4.1.129 HTS8
-
 Caulobacter vibrioides
2.4.1.129 HTS8
-
 Cereibacter sphaeroides
2.4.1.129 HTS8
-
 Escherichia coli
2.4.1.129 HTS8
-
 Mycobacterium tuberculosis
2.4.1.129 HTS8
-
 Staphylococcus aureus
2.4.1.129 moenomycin A
-
 Aquifex aeolicus
2.4.1.129 moenomycin A
-
 Bacillus subtilis
2.4.1.129 moenomycin A
-
 Caulobacter vibrioides
2.4.1.129 moenomycin A
-
 Cereibacter sphaeroides
2.4.1.129 moenomycin A
-
 Escherichia coli
2.4.1.129 moenomycin A
-
 Mycobacterium tuberculosis
2.4.1.129 moenomycin A
-
 Staphylococcus aureus
2.4.1.129 TS30153
-
 Aquifex aeolicus
2.4.1.129 TS30153
-
 Bacillus subtilis
2.4.1.129 TS30153
-
 Caulobacter vibrioides
2.4.1.129 TS30153
-
 Cereibacter sphaeroides
2.4.1.129 TS30153
-
 Escherichia coli
2.4.1.129 TS30153
-
 Mycobacterium tuberculosis
2.4.1.129 TS30153
-
 Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.129 Aquifex aeolicus
-
-
-
2.4.1.129 Bacillus subtilis
-
-
-
2.4.1.129 Caulobacter vibrioides
-
-
-
2.4.1.129 Cereibacter sphaeroides
-
-
-
2.4.1.129 Escherichia coli
-
-
-
2.4.1.129 Mycobacterium tuberculosis
-
-
-
2.4.1.129 Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.129 [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 Staphylococcus aureus [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-diphosphoundecaprenol + undecaprenyl diphosphate
-
 ?
2.4.1.129 [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 Bacillus subtilis [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-diphosphoundecaprenol + undecaprenyl diphosphate
-
 ?
2.4.1.129 [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 Escherichia coli [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-diphosphoundecaprenol + undecaprenyl diphosphate
-
 ?
2.4.1.129 [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 Cereibacter sphaeroides [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-diphosphoundecaprenol + undecaprenyl diphosphate
-
 ?
2.4.1.129 [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 Mycobacterium tuberculosis [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-diphosphoundecaprenol + undecaprenyl diphosphate
-
 ?
2.4.1.129 [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 Caulobacter vibrioides [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-diphosphoundecaprenol + undecaprenyl diphosphate
-
 ?
2.4.1.129 [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 Aquifex aeolicus [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-diphosphoundecaprenol + undecaprenyl diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.129 PBP1 isoform Bacillus subtilis
2.4.1.129 PBP1a
-
 Aquifex aeolicus
2.4.1.129 PBP1a isoform Escherichia coli
2.4.1.129 PBP1a isoform Caulobacter vibrioides
2.4.1.129 PBP1b isoform Escherichia coli
2.4.1.129 PBP2
-
 Staphylococcus aureus
2.4.1.129 PBP2 isoform Escherichia coli
2.4.1.129 PBP2 isoform Cereibacter sphaeroides
2.4.1.129 PBP2 isoform Caulobacter vibrioides
2.4.1.129 PBP2A isoform Bacillus subtilis
2.4.1.129 PBP2A isoform Caulobacter vibrioides
2.4.1.129 PBP2b isoform Caulobacter vibrioides
2.4.1.129 PBP2c isoform Bacillus subtilis
2.4.1.129 PBP2d isoform Bacillus subtilis
2.4.1.129 PBP3 isoform Bacillus subtilis
2.4.1.129 PBP3 isoform Escherichia coli
2.4.1.129 PBP4 isoform Bacillus subtilis
2.4.1.129 PBP7 isoform Escherichia coli
2.4.1.129 PBP8 isoform Escherichia coli
2.4.1.129 PBPA isoform Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.4.1.129 physiological function isoform PBP3 is required for localization of MurG to division site Escherichia coli