EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.43 | apolipoprotein A-I | required | Mus musculus | |
2.3.1.43 | apolipoprotein A-I | required | Oryctolagus cuniculus | |
2.3.1.43 | apolipoprotein A-I | required, other apolipoprotein are less effective | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.3.1.43 | additional information | enzyme deficiency phenotypes, overview. Generation of transgenic mice, monkeys, or rabbits overexpressing the human LCAT | Homo sapiens |
2.3.1.43 | additional information | overexpression of LCAT does not protect against diet-induced atherosclerosis, but in contrary does increase the atherosclerosis risk. LCAT knockout mice show markedly reduced plasma total cholesterol, cholesteryl esters, HDL-C, apolipoprotein A-I, and an increase in plasma triglycerides, the amount of alpha-HDl is decreased compared to wild-type mice | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.43 | sphingomyelin | - |
Homo sapiens | |
2.3.1.43 | sphingomyelin | - |
Mus musculus | |
2.3.1.43 | sphingomyelin | - |
Oryctolagus cuniculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.3.1.43 | extracellular | - |
Mus musculus | - |
- |
2.3.1.43 | extracellular | - |
Homo sapiens | - |
- |
2.3.1.43 | extracellular | - |
Oryctolagus cuniculus | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.43 | additional information | Homo sapiens | about 75% of plasma LCAT is associated with HDL | ? | - |
? | |
2.3.1.43 | phosphatidylcholine + cholesterol | Mus musculus | - |
cholesteryl ester + lysophosphatidylcholine | - |
? | |
2.3.1.43 | phosphatidylcholine + cholesterol | Homo sapiens | - |
cholesteryl ester + lysophosphatidylcholine | - |
? | |
2.3.1.43 | phosphatidylcholine + cholesterol | Oryctolagus cuniculus | - |
cholesteryl ester + lysophosphatidylcholine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.43 | Homo sapiens | - |
gene lcat | - |
2.3.1.43 | Mus musculus | - |
gene lcat | - |
2.3.1.43 | Oryctolagus cuniculus | - |
gene lcat | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.1.43 | blood plasma | - |
Mus musculus | - |
2.3.1.43 | blood plasma | - |
Oryctolagus cuniculus | - |
2.3.1.43 | blood plasma | about 75% of plasma LCAT is associated with HDL | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.43 | additional information | about 75% of plasma LCAT is associated with HDL | Homo sapiens | ? | - |
? | |
2.3.1.43 | additional information | the human enzyme prefers phospholipids with 18:1 or 18:2 fatty acids | Homo sapiens | ? | - |
? | |
2.3.1.43 | additional information | the mouse enzyme prefers phospholipids with 20:4 fatty acids | Mus musculus | ? | - |
? | |
2.3.1.43 | phosphatidylcholine + cholesterol | - |
Mus musculus | cholesteryl ester + lysophosphatidylcholine | - |
? | |
2.3.1.43 | phosphatidylcholine + cholesterol | - |
Homo sapiens | cholesteryl ester + lysophosphatidylcholine | - |
? | |
2.3.1.43 | phosphatidylcholine + cholesterol | - |
Oryctolagus cuniculus | cholesteryl ester + lysophosphatidylcholine | - |
? | |
2.3.1.43 | phosphatidylcholine + cholesterol | in a first step, LCAT hydrolyzes the sn-2 acyl group of phosphatidylcholine and binds it at Ser181. In a second step, the enzyme transfers and esterifies the fatty acid to the 3beta-hydroxyl group on the A-ring of free cholesterol to form cholesteryl ester using apolipoprotein A-I as cofactor | Mus musculus | cholesteryl ester + lysophosphatidylcholine | - |
? | |
2.3.1.43 | phosphatidylcholine + cholesterol | in a first step, LCAT hydrolyzes the sn-2 acyl group of phosphatidylcholine and binds it at Ser181. In a second step, the enzyme transfers and esterifies the fatty acid to the 3beta-hydroxyl group on the A-ring of free cholesterol to form cholesteryl ester using apolipoprotein A-I as cofactor | Homo sapiens | cholesteryl ester + lysophosphatidylcholine | - |
? | |
2.3.1.43 | phosphatidylcholine + cholesterol | in a first step, LCAT hydrolyzes the sn-2 acyl group of phosphatidylcholine and binds it at Ser181. In a second step, the enzyme transfers and esterifies the fatty acid to the 3beta-hydroxyl group on the A-ring of free cholesterol to form cholesteryl ester using apolipoprotein A-I as cofactor | Oryctolagus cuniculus | cholesteryl ester + lysophosphatidylcholine | - |
? | |
2.3.1.43 | phosphatidylethanolamine + cholesterol | - |
Mus musculus | cholesteryl ester + lysophosphatidylethanolamine | - |
? | |
2.3.1.43 | phosphatidylethanolamine + cholesterol | - |
Homo sapiens | cholesteryl ester + lysophosphatidylethanolamine | - |
? | |
2.3.1.43 | phosphatidylethanolamine + cholesterol | - |
Oryctolagus cuniculus | cholesteryl ester + lysophosphatidylethanolamine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.43 | LCAT | - |
Mus musculus |
2.3.1.43 | LCAT | - |
Homo sapiens |
2.3.1.43 | LCAT | - |
Oryctolagus cuniculus |
2.3.1.43 | lecithin: cholesterol acyltransferase | - |
Mus musculus |
2.3.1.43 | lecithin: cholesterol acyltransferase | - |
Homo sapiens |
2.3.1.43 | lecithin: cholesterol acyltransferase | - |
Oryctolagus cuniculus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.3.1.43 | malfunction | inborn enzyme deficiency leads to the fish-eye disease, as well as anemia, proteinuria, renal failure, hepatosplenomegaly, and lymphadenopathy | Homo sapiens |
2.3.1.43 | physiological function | LCAT might have a beneficial role in reducing atherosclerosis | Mus musculus |
2.3.1.43 | physiological function | LCAT might have a beneficial role in reducing atherosclerosis | Homo sapiens |
2.3.1.43 | physiological function | LCAT might have a beneficial role in reducing atherosclerosis | Oryctolagus cuniculus |