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Literature summary extracted from

  • Pula, G.; Mayr, U.; Evans, C.; Prokopi, M.; Vara, D.S.; Yin, X.; Astroulakis, Z.; Xiao, Q.; Hill, J.; Xu, Q.; Mayr, M.
    Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures (2009), Circ. Res., 104, 32-40.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.4.2.4 additional information gene silencing results in a significant increase in basal and oxidative stress-induced apoptosis, the effect is abrogated by supplementation with 2-deoxy-D-ribose-1-phosphate Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.4 5-bromo-6-amino-uracil enzyme inhibition results in a significant increase in basal and oxidative stress-induced apoptosis, the effect is abrogated by supplementation with 2-deoxy-D-ribose-1-phosphate Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.4 thymidine + phosphate Homo sapiens
-
 thymine + 2-deoxy-alpha-D-ribose 1-phosphate 2-deoxy-alpha-D-ribose 1-phosphate strongly promoted neovascularization ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.4 endothelial cell
-
 Homo sapiens
-
2.4.2.4 mononuclear cell from peripheral blood Homo sapiens
-
2.4.2.4 additional information enzyme expression analysis in cell and tissues, overview Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.4 thymidine + phosphate
-
 Homo sapiens thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?
2.4.2.4 thymidine + phosphate
-
 Homo sapiens thymine + 2-deoxy-alpha-D-ribose 1-phosphate 2-deoxy-alpha-D-ribose 1-phosphate strongly promoted neovascularization ?

General Information

EC Number General Information Comment Organism
2.4.2.4 physiological function thymidine phosphorylase is a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures, overview. The enzyme is a survival factor, it protects against apoptosis, stimulates endothelial cell migration and enhances wound healing in vitro and angiogenesis in vivo, overview Homo sapiens