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Literature summary extracted from

  • Roth, A.G.; Redmer, S.; Arenz, C.
    Potent inhibition of acid sphingomyelinase by phosphoinositide analogues (2009), ChemBioChem, 10, 2367-2374.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 1,3,5-tri-O-dodecylsulfonyl-D_myo-inositol
-
 Rattus norvegicus
3.1.4.12 1,3,5-tri-O-ethylsulfonyl-D-myo-inositol
-
 Rattus norvegicus
3.1.4.12 1,3,5-tri-O-methylsulfonyl-D-myo-inositol
-
 Rattus norvegicus
3.1.4.12 1,3,5-tri-O-octylsulfonyl-D-myo-inositol
-
 Rattus norvegicus
3.1.4.12 1-O-dodecylsulfonyl-D-myo-inositol 3,5-bisphosphate
-
 Rattus norvegicus
3.1.4.12 1-O-ethylsulfonyl-D-myo-inositol 3,5-bisphosphate
-
 Rattus norvegicus
3.1.4.12 1-O-hexylsulfonyl-D-myo-inositol 3,5-bisphosphate
-
 Rattus norvegicus
3.1.4.12 1-O-methylsulfonyl-D-myo-inositol 3,5-bisphosphate
-
 Rattus norvegicus
3.1.4.12 1-O-octylsulfonyl-D-myo-inositol 3,5-bisphosphate
-
 Rattus norvegicus
3.1.4.12 cis, cis-cyclohexane 1,3,5-trisphosphate barely inhibits aSMase even at a 0.1 mM concentration Rattus norvegicus
3.1.4.12 myo-inositol 1,3,5-trisphosphate
-
 Rattus norvegicus
3.1.4.12 myo-Inositol 3,5-bisphosphate
-
 Rattus norvegicus
3.1.4.12 phosphatidyl inositol 3,5-bisphosphate potent selective acid sphingomyelinase inhibitor Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.12 Mono Q column chromatography, gel filtration Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 sphingomyelin + H2O
-
 Rattus norvegicus N-acylsphingosine + choline phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 acid sphingomyelinase
-
 Rattus norvegicus
3.1.4.12 aSMase
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.4.12 0.0009
-
 in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus 1-O-dodecylsulfonyl-D-myo-inositol 3,5-bisphosphate
3.1.4.12 0.00093
-
 in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus phosphatidyl inositol 3,5-bisphosphate
3.1.4.12 0.004
-
 in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus 1-O-octylsulfonyl-D-myo-inositol 3,5-bisphosphate
3.1.4.12 0.0267
-
 in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus myo-inositol 1,3,5-trisphosphate
3.1.4.12 0.043
-
 in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus 1-O-hexylsulfonyl-D-myo-inositol 3,5-bisphosphate
3.1.4.12 0.1
-
 IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus cis, cis-cyclohexane 1,3,5-trisphosphate
3.1.4.12 0.1
-
 IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus 1,3,5-tri-O-methylsulfonyl-D-myo-inositol
3.1.4.12 0.1
-
 IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus 1,3,5-tri-O-ethylsulfonyl-D-myo-inositol
3.1.4.12 0.1
-
 IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus 1,3,5-tri-O-octylsulfonyl-D-myo-inositol
3.1.4.12 0.1
-
 IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus 1,3,5-tri-O-dodecylsulfonyl-D_myo-inositol
3.1.4.12 0.1
-
 IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus myo-Inositol 3,5-bisphosphate
3.1.4.12 0.1
-
 IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus 1-O-methylsulfonyl-D-myo-inositol 3,5-bisphosphate
3.1.4.12 0.1
-
 IC50 above 0.1 mM, in 100 mM NaOAc, pH 5.2, at 37°C Rattus norvegicus 1-O-ethylsulfonyl-D-myo-inositol 3,5-bisphosphate