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Literature summary extracted from

  • Staab, C.A.; Hellgren, M.; Grafstroem, R.C.; Hoeoeg, J.O.
    Medium-chain fatty acids and glutathione derivatives as inhibitors of S-nitrosoglutathione reduction mediated by alcohol dehydrogenase 3 (2009), Chem. Biol. Interact., 180, 113-118.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.284 expressed in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.284 decanedioic acid sebacic acid Homo sapiens
1.1.1.284 Decanoic acid capric acid Homo sapiens
1.1.1.284 dodecanedioic acid most efficient inhibitor Homo sapiens
1.1.1.284 dodecanoic acid lauric acid, most efficient inhibitor, competitively inhibits Homo sapiens
1.1.1.284 glutathione
-
 Homo sapiens
1.1.1.284 GSSG
-
 Homo sapiens
1.1.1.284 additional information not inhibited by 0.4 mM 2-aminodecanoic acid and 10 mM glutathionesulfonic acid Homo sapiens
1.1.1.284 Nonanoic acid pelargonic acid Homo sapiens
1.1.1.284 octanoic acid caprylic acid Homo sapiens
1.1.1.284 S-acetamidoglutathione
-
 Homo sapiens
1.1.1.284 S-Methylglutathione
-
 Homo sapiens
1.1.1.284 Tridecanoic acid tridecylic acid Homo sapiens
1.1.1.284 Undecanoic acid undecylic acid, most efficient inhibitor Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.284 Zinc for glutathione-derived ADH3 ligands, a nucleophilic group in coordination distance of the active site zinc is imperative for efficient binding Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.284 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.284 to homogeneity in a three-step procedure Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.284 S-nitrosoglutathione + NADH + H+
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.284 ADH3
-
 Homo sapiens
1.1.1.284 alcohol dehydrogenase 3
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.284 NADH
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.284 0.173
-
 dodecanedioic acid inhibition of S-nitrosoglutathione reduction Homo sapiens
1.1.1.284 0.177
-
 dodecanoic acid inhibition of S-nitrosoglutathione reduction Homo sapiens
1.1.1.284 0.19
-
 Undecanoic acid inhibition of S-nitrosoglutathione reduction Homo sapiens
1.1.1.284 0.224
-
 Tridecanoic acid inhibition of S-nitrosoglutathione reduction Homo sapiens
1.1.1.284 0.231
-
 Decanoic acid inhibition of S-nitrosoglutathione reduction Homo sapiens
1.1.1.284 0.437
-
 decanedioic acid inhibition of S-nitrosoglutathione reduction Homo sapiens
1.1.1.284 0.621
-
 Nonanoic acid inhibition of S-nitrosoglutathione reduction Homo sapiens
1.1.1.284 0.909
-
 octanoic acid inhibition of S-nitrosoglutathione reduction Homo sapiens
1.1.1.284 6.1
-
 S-acetamidoglutathione inhibition of S-nitrosoglutathione reduction Homo sapiens
1.1.1.284 15
-
 S-Methylglutathione inhibition of S-nitrosoglutathione reduction Homo sapiens
1.1.1.284 21
-
 glutathione inhibition of S-nitrosoglutathione reduction Homo sapiens
1.1.1.284 50
-
 GSSG with 10 and 20 mM, inhibition of S-nitrosoglutathione reduction Homo sapiens