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Literature summary extracted from

  • Liu, S.; Murph, M.; Panupinthu, N.; Mills, G.B.
    ATX-LPA receptor axis in inflammation and cancer (2009), Cell Cycle, 8, 3695-3701.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.1.4.39 medicine the autotaxin-lysophosphatidic acid receptor axis is a rich therapeutic target in cancer Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.39 expressed in Mus musculus Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.39 lysophosphatidylcholine + H2O Homo sapiens
-
 lysophosphatidic acid + choline
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.39 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.39 breast cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.39 lysophosphatidylcholine + H2O
-
 Homo sapiens lysophosphatidic acid + choline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.39 ATX
-
 Homo sapiens
3.1.4.39 autotaxin
-
 Homo sapiens
3.1.4.39 lysoPLD
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.4.39 physiological function the autotaxin-lysophosphatidic acid receptor axis plays a causal role in breast tumorigenesis and cancer-related inflammation Homo sapiens