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Literature summary extracted from

  • Mariano, S.; Roos, A.K.; Mowbray, S.L.; Salmon, L.
    Competitive inhibitors of type B ribose 5-phosphate isomerases: design, synthesis and kinetic evaluation of new D-allose and D-allulose 6-phosphate derivatives (2009), Carbohydr. Res., 344, 869-880.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.1.6 5-phospho-D-ribonamide
-
 Escherichia coli
5.3.1.6 5-phospho-D-ribonamide
-
 Mycobacterium tuberculosis
5.3.1.6 5-phospho-D-ribonate competitive inhibitor of a Rpi, displays specific inhibition of Mycobacterium tuberculosis RpiB versus Escherichia coli RpiB, inhibition kinetics, overview Escherichia coli
5.3.1.6 5-phospho-D-ribonate very strong competitive inhibitor of a Rpi, specific inhibition of Mycobacterium tuberculosis RpiB versus Escherichia coli RpiB, inhibition kinetics, overview Mycobacterium tuberculosis
5.3.1.6 5-phospho-D-ribonohydroxamic acid
-
 Escherichia coli
5.3.1.6 5-phospho-D-ribonohydroxamic acid
-
 Mycobacterium tuberculosis
5.3.1.6 additional information substrate-derived enzyme inhibitor design and synthesis of analogues of the 6-carbon high-energy intermediate postulated for the D-allose 6-phosphate to D-allulose 6-phosphate isomerization reaction, overview Escherichia coli
5.3.1.6 additional information substrate-derived enzyme inhibitor design and synthesis of analogues of the 6-carbon high-energy intermediate postulated for the D-allose 6-phosphate to D-allulose 6-phosphate isomerization reaction, overview Mycobacterium tuberculosis
5.3.1.6 N-(5-phospho-D-ribonoyl)-gamma-aminobutanoate
-
 Escherichia coli
5.3.1.6 N-(5-phospho-D-ribonoyl)-gamma-aminobutanoate
-
 Mycobacterium tuberculosis
5.3.1.6 N-(5-phospho-D-ribonoyl)-glycine poor inhibition with substrate D-ribose 5-phosphate, no inhibition with substrate D-allose 5-phosphate Escherichia coli
5.3.1.6 N-(5-phospho-D-ribonoyl)-glycine
-
 Mycobacterium tuberculosis
5.3.1.6 N-(5-phospho-D-ribonoyl)-hydrazine
-
 Escherichia coli
5.3.1.6 N-(5-phospho-D-ribonoyl)-hydrazine
-
 Mycobacterium tuberculosis
5.3.1.6 N-(5-phospho-D-ribonoyl)-methylamine
-
 Escherichia coli
5.3.1.6 N-(5-phospho-D-ribonoyl)-methylamine
-
 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.1.6 D-ribose 5-phosphate Escherichia coli
-
 D-ribulose 5-phosphate
-
 r
5.3.1.6 D-ribose 5-phosphate Mycobacterium tuberculosis
-
 D-ribulose 5-phosphate
-
 r
5.3.1.6 D-ribose 5-phosphate Mycobacterium tuberculosis H37Rv
-
 D-ribulose 5-phosphate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
5.3.1.6 Escherichia coli
-
 gene rpiB
-
5.3.1.6 Mycobacterium tuberculosis P9WKD7 gene rpiB
-
5.3.1.6 Mycobacterium tuberculosis H37Rv P9WKD7 gene rpiB
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.1.6 D-allose 6-phosphate
-
 Escherichia coli D-allulose 6-phosphate
-
 r
5.3.1.6 D-allose 6-phosphate
-
 Mycobacterium tuberculosis D-allulose 6-phosphate
-
 r
5.3.1.6 D-allose 6-phosphate
-
 Mycobacterium tuberculosis H37Rv D-allulose 6-phosphate
-
 r
5.3.1.6 D-ribose 5-phosphate
-
 Escherichia coli D-ribulose 5-phosphate
-
 r
5.3.1.6 D-ribose 5-phosphate
-
 Mycobacterium tuberculosis D-ribulose 5-phosphate
-
 r
5.3.1.6 D-ribose 5-phosphate
-
 Mycobacterium tuberculosis H37Rv D-ribulose 5-phosphate
-
 r
5.3.1.6 additional information enzyme substrate synthesis, overview Escherichia coli ?
-
 ?
5.3.1.6 additional information enzyme substrate synthesis, overview Mycobacterium tuberculosis ?
-
 ?
5.3.1.6 additional information enzyme substrate synthesis, overview Mycobacterium tuberculosis H37Rv ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.1.6 D-Ribose 5-phosphate isomerase
-
 Escherichia coli
5.3.1.6 D-Ribose 5-phosphate isomerase
-
 Mycobacterium tuberculosis
5.3.1.6 EcRpiB
-
 Escherichia coli
5.3.1.6 MtRpiB
-
 Mycobacterium tuberculosis
5.3.1.6 RpiB
-
 Escherichia coli
5.3.1.6 RpiB
-
 Mycobacterium tuberculosis
5.3.1.6 type B ribose 5-phosphate isomerase
-
 Escherichia coli
5.3.1.6 type B ribose 5-phosphate isomerase
-
 Mycobacterium tuberculosis
5.3.1.6 type B Rpi
-
 Escherichia coli
5.3.1.6 type B Rpi
-
 Mycobacterium tuberculosis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
5.3.1.6 37
-
 assay at Escherichia coli
5.3.1.6 37
-
 assay at Mycobacterium tuberculosis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.3.1.6 7.5
-
 assay at Escherichia coli
5.3.1.6 7.5
-
 assay at Mycobacterium tuberculosis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
5.3.1.6 0.009
-
 5-phospho-D-ribonate pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate Mycobacterium tuberculosis
5.3.1.6 0.04
-
 5-phospho-D-ribonamide pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate Mycobacterium tuberculosis
5.3.1.6 0.07
-
 5-phospho-D-ribonamide pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate Escherichia coli
5.3.1.6 0.09
-
 5-phospho-D-ribonohydroxamic acid pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate Escherichia coli
5.3.1.6 0.11
-
 N-(5-phospho-D-ribonoyl)-methylamine pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate Mycobacterium tuberculosis
5.3.1.6 0.18
-
 N-(5-phospho-D-ribonoyl)-methylamine pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate Escherichia coli
5.3.1.6 0.26
-
 5-phospho-D-ribonohydroxamic acid pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate Mycobacterium tuberculosis
5.3.1.6 0.34
-
 N-(5-phospho-D-ribonoyl)-glycine pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate Mycobacterium tuberculosis
5.3.1.6 0.43
-
 5-phospho-D-ribonohydroxamic acid pH 7.5, 37°C, RpiB, substrate is D-allose 5-phosphate Escherichia coli
5.3.1.6 1.9
-
 N-(5-phospho-D-ribonoyl)-hydrazine pH 7.5, 37°C, RpiB, substrate is D-allose 5-phosphate Escherichia coli

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
5.3.1.6 0.031
-
 pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate Mycobacterium tuberculosis 5-phospho-D-ribonate
5.3.1.6 0.17
-
 pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate Escherichia coli 5-phospho-D-ribonohydroxamic acid
5.3.1.6 0.19
-
 pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate Mycobacterium tuberculosis N-(5-phospho-D-ribonoyl)-methylamine
5.3.1.6 0.2
-
 pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate Escherichia coli 5-phospho-D-ribonamide
5.3.1.6 0.22
-
 pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate Mycobacterium tuberculosis 5-phospho-D-ribonamide
5.3.1.6 0.35
-
 pH 7.5, 37°C, RpiB, substrate is D-allose 5-phosphate Escherichia coli N-(5-phospho-D-ribonoyl)-methylamine
5.3.1.6 0.36
-
 pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate Escherichia coli N-(5-phospho-D-ribonoyl)-methylamine
5.3.1.6 0.44
-
 pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate Mycobacterium tuberculosis 5-phospho-D-ribonohydroxamic acid
5.3.1.6 0.57
-
 pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate Mycobacterium tuberculosis N-(5-phospho-D-ribonoyl)-glycine
5.3.1.6 0.62
-
 pH 7.5, 37°C, RpiB, substrate is D-allose 5-phosphate Escherichia coli 5-phospho-D-ribonohydroxamic acid
5.3.1.6 1
-
 pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate Mycobacterium tuberculosis N-(5-phospho-D-ribonoyl)-hydrazine
5.3.1.6 1.31
-
 pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate Escherichia coli 5-phospho-D-ribonate
5.3.1.6 1.33
-
 pH 7.5, 37°C, RpiB, substrate is D-allose 5-phosphate Escherichia coli 5-phospho-D-ribonamide
5.3.1.6 1.42
-
 pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate Mycobacterium tuberculosis N-(5-phospho-D-ribonoyl)-gamma-aminobutanoate
5.3.1.6 1.6
-
 pH 7.5, 37°C, RpiB, substrate is D-allose 5-phosphate Escherichia coli N-(5-phospho-D-ribonoyl)-gamma-aminobutanoate
5.3.1.6 2
-
 pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate Escherichia coli N-(5-phospho-D-ribonoyl)-gamma-aminobutanoate
5.3.1.6 9
-
 pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate Escherichia coli N-(5-phospho-D-ribonoyl)-glycine

General Information

EC Number General Information Comment Organism
5.3.1.6 metabolism ribose 5-phosphate isomerase is a key enzyme of the pentose phosphate pathway Escherichia coli
5.3.1.6 metabolism ribose 5-phosphate isomerase is a key enzyme of the pentose phosphate pathway Mycobacterium tuberculosis