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Literature summary extracted from

  • Wang, H.; Wang, R.; Zhao, Z.; Ji, Z.; Xu, S.; Holscher, C.; Sheng, S.
    Coexistences of insulin signaling-related proteins and choline acetyltransferase in neurons (2009), Brain Res., 1249, 237-243.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.6 diagnostics ChAT is selected as a marker of cholinergicneurons. In the CA1 region of hippocampus of mice, several of the insulin signaling-related proteins are co-located with ChAT, and most double immunoreactive positive cells are pyramidal cells Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.6 cytoplasm
-
 Mus musculus 5737
-
2.3.1.6 additional information immunofluorescent localization study, overview Mus musculus
-
-
2.3.1.6 nucleus
-
 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.6 acetyl-CoA + choline Mus musculus
-
 CoA + O-acetylcholine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.6 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.6 hippocampus cholinergic neuron-specific ChAT in the CA1 region of hippocampus Mus musculus
-
2.3.1.6 additional information immunofluorescent localization study, overview Mus musculus
-
2.3.1.6 neuron
-
 Mus musculus
-
2.3.1.6 pyramidal cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.6 acetyl-CoA + choline
-
 Mus musculus CoA + O-acetylcholine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.6 ChAT
-
 Mus musculus
2.3.1.6 choline acetyltransferase
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.3.1.6 physiological function ChAT is the rate-limiting enzyme of generating acetylcholine, which is synthesized in cholinergic neuronal cell bodies. Insulin signaling may play an important part in the activities of cholinergic neurons Mus musculus