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Literature summary extracted from

  • Deguchi, A.; Hata, M.; Uhara, T.; Yamauchi, T.
    Domain structure responsible for the different properties between alpha and beta Ca2+/calmodulin-dependent protein kinase II analyzed by their chimera enzymes (2008), Brain Res., 1238, 1-11.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 Calmodulin
-
 Mammalia

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.17 wild-type alpha, beta, and chimera constructs are generated using the vectors pBluescript, pcDNA3 and pEGFP-C1 Mammalia

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.17 alpha11beta chimera Ca2+/calmodulin-dependent protein kinase II, exon 1-11 isoform alpha, exon 12-20 isoform beta, affinity for calmodulin, type low Mammalia
2.7.11.17 alpha2beta chimera Ca2+/calmodulin-dependent protein kinase II, exon 1-2 isoform alpha, exon 3-20 isoform beta, affinity for calmodulin, type middle Mammalia
2.7.11.17 alpha9beta chimera Ca2+/calmodulin-dependent protein kinase II, exon 1-9 isoform alpha, exon 10-20 isoform beta, affinity for calmodulin, type middle Mammalia
2.7.11.17 beta11alpha chimera Ca2+/calmodulin-dependent protein kinase II, exon 1-11 isoform beta, exon 12-17 isoform alpha, affinity for calmodulin, high Mammalia
2.7.11.17 beta2alpha chimera Ca2+/calmodulin-dependent protein kinase II, exon 1-2 isoform beta, exon 3-17 isoform alpha, affinity for calmodulin, type lower than low Mammalia
2.7.11.17 beta9alpha | chimera Ca2+/calmodulin-dependent protein kinase II, exon 1-9 isoform beta, exon 10-17 isoform alpha, affinity for calmodulin, type lower than low Mammalia

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+
-
 Mammalia

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.11.17 50000
-
 isoform alpha, monomer, determined by SDS-PAGE and Western blot analysis Mammalia
2.7.11.17 60000
-
 isoform beta, monomer, determined by SDS-PAGE and Western blot analysis Mammalia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 ATP + a protein Mammalia
-
 ADP + a phosphoprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Mammalia
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.17 phosphoprotein autophosphorylation Mammalia

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 ATP + a protein
-
 Mammalia ADP + a phosphoprotein
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.17 oligomer
-
 Mammalia

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 alpha Ca2+/calmodulin-dependent protein kinase II isoform alpha Mammalia
2.7.11.17 beta Ca2+/calmodulin-dependent protein kinase II isoform beta Mammalia
2.7.11.17 CaM kinase II
-
 Mammalia

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Mammalia