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Literature summary extracted from

  • Nelson, K.T.; Prohaska, J.R.
    Copper deficiency in rodents alters dopamine beta-mono-oxygenase activity, mRNA and protein level (2009), Br. J. Nutr., 102, 18-28.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.14.17.1 medicine adequate dietary Cu is essential to support DBM function in vivo Mus musculus
1.14.17.1 medicine adequate dietary Cu is essential to support DBM function in vivo Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.17.1 additional information Cu deficiency limits DBM activity in vivo Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.17.1 75000
-
 Western blot analysis Mus musculus
1.14.17.1 75000
-
 Western blot analysis Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.1 Mus musculus
-
 Hsd:ICR (CD-1) outbred albino mice, postnatal day 27 male mice and day 28 male mice
-
1.14.17.1 Rattus norvegicus
-
 Holtzman rats, postnatal day 24 male rats and day 26 male rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.17.1 adrenal gland
-
 Mus musculus
-
1.14.17.1 adrenal gland
-
 Rattus norvegicus
-
1.14.17.1 heart lowest level of all tissues Rattus norvegicus
-
1.14.17.1 additional information medulla oblongata/pons Rattus norvegicus
-
1.14.17.1 vas deferens
-
 Rattus norvegicus
-
1.14.17.1 vas deferens DBM protein is present in Cu-negative samples but not in Cu-positive samples Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.17.1 tyramine + ascorbate + O2
-
 Mus musculus octopamine + dehydroascorbate + H2O
-
 ?
1.14.17.1 tyramine + ascorbate + O2
-
 Rattus norvegicus octopamine + dehydroascorbate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.17.1 DBM
-
 Mus musculus
1.14.17.1 DBM
-
 Rattus norvegicus
1.14.17.1 dopamine beta-mono-oxygenase
-
 Mus musculus
1.14.17.1 dopamine beta-mono-oxygenase
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
1.14.17.1 Rattus norvegicus Cu-negative samples have significantly higher DBM activity than Cu-positive samples in both adrenal glands (2.4fold) and medulla oblongata/pons (0.9fold), but not vas deferens. No correlation between higher DBM mRNA and lower noradrenaline in Cu-negative tissues up
1.14.17.1 Mus musculus DBM protein abundance in adrenal glands is higher in the Cu-negative samples compared with Cu-positive samples up