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Literature summary extracted from

  • Melancon, C.E.; Schultz, P.G.
    One plasmid selection system for the rapid evolution of aminoacyl-tRNA synthetases (2009), Bioorg. Med. Chem. Lett., 19, 3845-3847.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
6.1.1.1 biotechnology a rapid, straightforward, one plasmid dual positive/negative selection system for the evolution of aminoacyl-tRNA synthetases with altered specifities in Escherichia coli is developed Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.1 ATP + L-tyrosine + tRNATyr Methanocaldococcus jannaschii
-
 AMP + diphosphate + L-tyrosyl-tRNATyr
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.1 Methanocaldococcus jannaschii
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.1 ATP + L-tyrosine + tRNATyr
-
 Methanocaldococcus jannaschii AMP + diphosphate + L-tyrosyl-tRNATyr
-
 ?
6.1.1.1 ATP + p-iodophenylalanine + tRNATyr a variant of the Methanococcus jannaschii tyrosyl synthetase that selectively incorporates para-iodophenylalanine in response to an amber stop codon is identified Methanocaldococcus jannaschii AMP + diphosphate + p-iodophenylalanyl-tRNATyr
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.1 tRNATyr/tyrosyl-tRNA synthetase
-
 Methanocaldococcus jannaschii
6.1.1.1 tyrosyl synthetase
-
 Methanocaldococcus jannaschii
6.1.1.1 Tyrosyl-tRNA synthetase
-
 Methanocaldococcus jannaschii

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.1 ATP
-
 Methanocaldococcus jannaschii