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Literature summary extracted from

  • Garrido, F.; Alfonso, C.; Taylor, J.C.; Markham, G.D.; Pajares, M.A.
    Subunit association as the stabilizing determinant for archaeal methionine adenosyltransferases (2009), Biochim. Biophys. Acta, 1794, 1082-1090.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.5.1.6 construction of a 3D-homology model. This model predicts preservation of the chain topology and three-domain organization typical of this family, locates the least stable structural elements at the flat contact surface between monomers, and shows that alterations in all three domains are required for dimer dissociation Methanocaldococcus jannaschii

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.6 W387F kinetic data Methanocaldococcus jannaschii
2.5.1.6 W387F/Y120W kinetic data Methanocaldococcus jannaschii
2.5.1.6 W387F/Y170W kinetic data Methanocaldococcus jannaschii
2.5.1.6 W387F/Y226W kinetic data Methanocaldococcus jannaschii
2.5.1.6 W387F/Y233W 4.9fold increase in kcat value. Mutant shows three transitions in urea titration curve, contrary to two transitions of wild-type Methanocaldococcus jannaschii
2.5.1.6 W387F/Y255W fluorescence intensity reduced to 18% of wild-type Methanocaldococcus jannaschii
2.5.1.6 W387F/Y267W kinetic data Methanocaldococcus jannaschii
2.5.1.6 W387F/Y273W kinetic data Methanocaldococcus jannaschii
2.5.1.6 W387F/Y323W kinetic data Methanocaldococcus jannaschii
2.5.1.6 W387F/Y344W kinetic data Methanocaldococcus jannaschii
2.5.1.6 W387F/Y371W shows one transition in urea titration curve, contrary to two transitions of wild-type Methanocaldococcus jannaschii
2.5.1.6 W387F/Y49W decrease in kcat value by 32% Methanocaldococcus jannaschii
2.5.1.6 W387F/Y72W kinetic data Methanocaldococcus jannaschii
2.5.1.6 W387F/Y85W kinetic data Methanocaldococcus jannaschii

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.6 0.1
-
ATP mutant W387F/Y170W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.1
-
ATP mutant W387F/Y226W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.11
-
ATP mutant W387F, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.11
-
ATP mutant W387F/Y371W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.11
-
ATP mutant W387F/Y72W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.13
-
ATP mutant W387F/Y120W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.13
-
L-methionine mutant W387F/Y323W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.13
-
L-methionine mutant W387F/Y72W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.18
-
ATP mutant W387F/Y49W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.19
-
ATP mutant W387F/Y255W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.19
-
ATP wild-type, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.2
-
ATP mutant W387F/Y233W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.2
-
ATP mutant W387F/Y267W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.21
-
ATP mutant W387F/Y85W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.22
-
ATP mutant W387F/Y323W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.22
-
ATP mutant W387F/Y344W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.24
-
ATP mutant W387F/Y273W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.25
-
L-methionine mutant W387F/Y371W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.3
-
L-methionine mutant W387F/Y226W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.3
-
L-methionine mutant W387F/Y273W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.31
-
L-methionine mutant W387F, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.31
-
L-methionine wild-type, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.33
-
L-methionine mutant W387F/Y344W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.45
-
L-methionine mutant W387F/Y267W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.47
-
L-methionine mutant W387F/Y233W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.5
-
L-methionine mutant W387F/Y255W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.54
-
L-methionine mutant W387F/Y120W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.57
-
L-methionine mutant W387F/Y85W, 55°C Methanocaldococcus jannaschii
2.5.1.6 0.66
-
L-methionine mutant W387F/Y49W, 55°C Methanocaldococcus jannaschii
2.5.1.6 1
-
L-methionine mutant W387F/Y170W, 55°C Methanocaldococcus jannaschii

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.6 Methanocaldococcus jannaschii Q58605
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.6 ATP + L-methionine + H2O
-
Methanocaldococcus jannaschii phosphate + diphosphate + S-adenosyl-L-methionine
-
?

Subunits

EC Number Subunits Comment Organism
2.5.1.6 More high stability of Methanococcus jannaschii enzyme derives largely from a tight association of its subunits in the dimer. The least stable structural elements are the C-terminal ends of beta-strands E2 and E6, and the N-terminus of E3 Methanocaldococcus jannaschii

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.5.1.6 1
-
L-methionine mutant W387F/Y49W, 55°C Methanocaldococcus jannaschii
2.5.1.6 1.46
-
L-methionine wild-type, 55°C Methanocaldococcus jannaschii
2.5.1.6 1.54
-
L-methionine mutant W387F/Y273W, 55°C Methanocaldococcus jannaschii
2.5.1.6 1.62
-
L-methionine mutant W387F/Y323W, 55°C Methanocaldococcus jannaschii
2.5.1.6 1.62
-
L-methionine mutant W387F/Y72W, 55°C Methanocaldococcus jannaschii
2.5.1.6 1.85
-
L-methionine mutant W387F, 55°C Methanocaldococcus jannaschii
2.5.1.6 2.31
-
L-methionine mutant W387F/Y267W, 55°C Methanocaldococcus jannaschii
2.5.1.6 2.39
-
L-methionine mutant W387F/Y170W, 55°C Methanocaldococcus jannaschii
2.5.1.6 2.39
-
L-methionine mutant W387F/Y255W, 55°C Methanocaldococcus jannaschii
2.5.1.6 2.77
-
L-methionine mutant W387F/Y85W, 55°C Methanocaldococcus jannaschii
2.5.1.6 2.85
-
L-methionine mutant W387F/Y344W, 55°C Methanocaldococcus jannaschii
2.5.1.6 3.31
-
L-methionine mutant W387F/Y120W, 55°C Methanocaldococcus jannaschii
2.5.1.6 4
-
L-methionine mutant W387F/Y371W, 55°C Methanocaldococcus jannaschii
2.5.1.6 5.08
-
L-methionine mutant W387F/Y226W, 55°C Methanocaldococcus jannaschii
2.5.1.6 7.24
-
L-methionine mutant W387F/Y233W, 55°C Methanocaldococcus jannaschii