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Literature summary extracted from

  • Riederer, M.; Erwa, W.; Zimmermann, R.; Frank, S.; Zechner, R.
    Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine (2009), Atherosclerosis, 204, 412-417.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.1 additional information elevated enzyme activity during cell differentiation in adipose tissue Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.1 1-methylnicotinamide product inhibition Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.1 S-adenosyl-L-methionine + nicotinamide Mus musculus
-
 S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?
2.1.1.1 S-adenosyl-L-methionine + nicotinamide Homo sapiens
-
 S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.1 Homo sapiens
-
-
-
2.1.1.1 Mus musculus
-
 female and male C57BL/6J mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.1 3T3-L1 cell elevated enzyme activity during cell differentiation in adipose tissue Mus musculus
-
2.1.1.1 adipocyte
-
 Homo sapiens
-
2.1.1.1 adipocyte NNMT expression profile, overview Mus musculus
-
2.1.1.1 adipose tissue
-
 Homo sapiens
-
2.1.1.1 adipose tissue expression analysis, overview Mus musculus
-
2.1.1.1 embryonic fibroblast
-
 Mus musculus
-
2.1.1.1 liver
-
 Homo sapiens
-
2.1.1.1 liver expression analysis, overview Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.1 S-adenosyl-L-methionine + nicotinamide
-
 Mus musculus S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?
2.1.1.1 S-adenosyl-L-methionine + nicotinamide
-
 Homo sapiens S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.1 NNMT
-
 Mus musculus
2.1.1.1 NNMT
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.1 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.1 7.2
-
 assay at Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.1 S-adenosyl-L-methionine
-
 Mus musculus
2.1.1.1 S-adenosyl-L-methionine
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.1.1.1 Homo sapiens the enzyme is induced by nicotinic acid in adipose tissue up
2.1.1.1 Mus musculus the enzyme is induced by nicotinic acid in white adipose tissue, but chronic treatment does not cause hyperhomocysteinemia, overview up