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Literature summary extracted from

  • Garcia-Effron, G.; Lee, S.; Park, S.; Cleary, J.D.; Perlin, D.S.
    Effect of Candida glabrata FKS1 and FKS2 mutations on echinocandin sensitivity and kinetics of 1,3-beta-D-glucan synthase: implication for the existing susceptibility breakpoint (2009), Antimicrob. Agents Chemother., 53, 3690-3699.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.34 genotyping Nakaseomyces glabratus

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.34 A1895G mutation of Fks1p Nakaseomyces glabratus
2.4.1.34 D632E mutation of Fks1p Nakaseomyces glabratus
2.4.1.34 D632G mutation of Fks1p Nakaseomyces glabratus
2.4.1.34 D632Y/R1377STOP mutation of Fks2p and Fks1p Nakaseomyces glabratus
2.4.1.34 D666E mutation of Fks2p Nakaseomyces glabratus
2.4.1.34 D666G mutation of Fks2p Nakaseomyces glabratus
2.4.1.34 F625S mutation of Fks1p Nakaseomyces glabratus
2.4.1.34 F659del mutation of Fks2p Nakaseomyces glabratus
2.4.1.34 F659S mutation of Fks2p Nakaseomyces glabratus
2.4.1.34 F659V mutation of Fks2p Nakaseomyces glabratus
2.4.1.34 G1894T mutation of Fks1p Nakaseomyces glabratus
2.4.1.34 additional information inhibition profile of wild-type and mutant enzymes with antifungal drugs, overview Nakaseomyces glabratus
2.4.1.34 P667T mutation of Fks2p Nakaseomyces glabratus
2.4.1.34 S629P mutation of Fks1p Nakaseomyces glabratus
2.4.1.34 S663P mutation of Fks2p Nakaseomyces glabratus
2.4.1.34 T1874C mutation of Fks1p Nakaseomyces glabratus
2.4.1.34 T1885C mutation of Fks1p Nakaseomyces glabratus
2.4.1.34 T1896G mutation of Fks1p Nakaseomyces glabratus
2.4.1.34 W1375L mutation of Fks2p Nakaseomyces glabratus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.34 anidulafungin an antifungal echinocandin drug, inhibition profile of wild-type and mutant enzymes Nakaseomyces glabratus
2.4.1.34 caspofungin an antifungal echinocandin drug, inhibition profile of wild-type and mutant enzymes Nakaseomyces glabratus
2.4.1.34 micafungin an antifungal echinocandin drug, inhibition profile of wild-type and mutant enzymes Nakaseomyces glabratus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.34 additional information
-
 additional information kinetics of wild-type and mutant enzymes, overview Nakaseomyces glabratus
2.4.1.34 0.1
-
 [(1,3)-beta-D-glucosyl]n enzyme from wild-type strain 3168 Nakaseomyces glabratus
2.4.1.34 0.12
-
 [(1,3)-beta-D-glucosyl]n enzyme from wild-type strain 218 Nakaseomyces glabratus
2.4.1.34 0.13
-
 [(1,3)-beta-D-glucosyl]n enzyme from wild-type strain 90030 Nakaseomyces glabratus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.34 UDP-glucose + [(1,3)-beta-D-glucosyl]n Nakaseomyces glabratus
-
 UDP + [(1,3)-beta-D-glucosyl]n+1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.34 Nakaseomyces glabratus
-
 Fifteen clinical strains, e.g. wild-type strains 90030, 218, and 3168
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.34 UDP-glucose + [(1,3)-beta-D-glucosyl]n
-
 Nakaseomyces glabratus UDP + [(1,3)-beta-D-glucosyl]n+1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.34 1,3-beta-D-glucan synthase
-
 Nakaseomyces glabratus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.1.34 additional information
-
 inhibitory potency of antifungal echinocandin drugs on different wild-type and on mutant strains, overview Nakaseomyces glabratus additional information