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Literature summary extracted from

  • Khosla, C.; Tang, Y.; Chen, A.Y.; Schnarr, N.A.; Cane, D.E.
    Structure and mechanism of the 6-deoxyerythronolide B synthase (2007), Annu. Rev. Biochem., 76, 195-221.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.94 heterologous expression in Streptomyces coelicolor and Escherichia coli Saccharopolyspora erythraea

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.1.94
-
 Saccharopolyspora erythraea

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.94 propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+ Saccharopolyspora erythraea
-
 6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.94 Saccharopolyspora erythraea
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.94
-
 Saccharopolyspora erythraea

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.94 propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+
-
 Saccharopolyspora erythraea 6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.94 oligomer the polyketide product is synthesized by the processive action of a loading didomain, six extension modules and a terminal thioesterase domain, as a minimal requirement for chain extension, each module contains a set of three functional domains, a ketosynthase, an acyltransferae, and an acyl carrier protein Saccharopolyspora erythraea

Synonyms

EC Number Synonyms Comment Organism
2.3.1.94 6-deoxyerythronolide B synthase
-
 Saccharopolyspora erythraea
2.3.1.94 DEBS
-
 Saccharopolyspora erythraea
2.3.1.94 PKS
-
 Saccharopolyspora erythraea
2.3.1.94 polyketide synthase
-
 Saccharopolyspora erythraea