Literature summary extracted from

Bale, S.; Ealick, S.E.
Structural biology of S-adenosylmethionine decarboxylase (2010), Amino Acids, 38, 451-460.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
4.1.1.50	putrescine	-	Homo sapiens

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
4.1.1.50	-	Trypanosoma brucei
4.1.1.50	-	Homo sapiens
4.1.1.50	-	Thermotoga maritima
4.1.1.50	-	Solanum tuberosum
4.1.1.50	-	Aquifex aeolicus

Protein Variants

EC Number	Protein Variants	Comment	Organism
4.1.1.50	C82A	the mutant shows decreased kcat compared to the wild type enzyme	Homo sapiens
4.1.1.50	H243A	the mutation traps the enzyme in the ester form	Homo sapiens
4.1.1.50	S68A	themutant lacks the hydroxyl group necessary for processing and traps the enzyme in a form similar to the proenzyme	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism
4.1.1.50	4-amidinoindan-1-one-2'-amidinohydrazone	-	Aquifex aeolicus
4.1.1.50	4-amidinoindan-1-one-2'-amidinohydrazone	-	Homo sapiens
4.1.1.50	4-amidinoindan-1-one-2'-amidinohydrazone	-	Solanum tuberosum
4.1.1.50	4-amidinoindan-1-one-2'-amidinohydrazone	-	Thermotoga maritima
4.1.1.50	4-amidinoindan-1-one-2'-amidinohydrazone	-	Trypanosoma brucei
4.1.1.50	5'-deoxy-5'-(dimethyl-sulfonio)adenosine	-	Aquifex aeolicus
4.1.1.50	5'-deoxy-5'-(dimethyl-sulfonio)adenosine	-	Homo sapiens
4.1.1.50	5'-deoxy-5'-(dimethyl-sulfonio)adenosine	-	Solanum tuberosum
4.1.1.50	5'-deoxy-5'-(dimethyl-sulfonio)adenosine	-	Thermotoga maritima
4.1.1.50	5'-deoxy-5'-(dimethyl-sulfonio)adenosine	-	Trypanosoma brucei
4.1.1.50	5'-deoxy-5'-(N-dimethyl)amino-8-methyl adenosine	-	Aquifex aeolicus
4.1.1.50	5'-deoxy-5'-(N-dimethyl)amino-8-methyl adenosine	-	Homo sapiens
4.1.1.50	5'-deoxy-5'-(N-dimethyl)amino-8-methyl adenosine	-	Solanum tuberosum
4.1.1.50	5'-deoxy-5'-(N-dimethyl)amino-8-methyl adenosine	-	Thermotoga maritima
4.1.1.50	5'-deoxy-5'-(N-dimethyl)amino-8-methyl adenosine	-	Trypanosoma brucei
4.1.1.50	5'-deoxy-5'-[N-methyl-N-(3-hydrazino-propyl)amino]adenosine	-	Aquifex aeolicus
4.1.1.50	5'-deoxy-5'-[N-methyl-N-(3-hydrazino-propyl)amino]adenosine	-	Homo sapiens
4.1.1.50	5'-deoxy-5'-[N-methyl-N-(3-hydrazino-propyl)amino]adenosine	-	Solanum tuberosum
4.1.1.50	5'-deoxy-5'-[N-methyl-N-(3-hydrazino-propyl)amino]adenosine	-	Thermotoga maritima
4.1.1.50	5'-deoxy-5'-[N-methyl-N-(3-hydrazino-propyl)amino]adenosine	-	Trypanosoma brucei
4.1.1.50	5'-deoxy-5'-[N-methyl-N-[(2-aminooxy)-ethyl]amino]adenosine	-	Aquifex aeolicus
4.1.1.50	5'-deoxy-5'-[N-methyl-N-[(2-aminooxy)-ethyl]amino]adenosine	-	Homo sapiens
4.1.1.50	5'-deoxy-5'-[N-methyl-N-[(2-aminooxy)-ethyl]amino]adenosine	-	Solanum tuberosum
4.1.1.50	5'-deoxy-5'-[N-methyl-N-[(2-aminooxy)-ethyl]amino]adenosine	-	Thermotoga maritima
4.1.1.50	5'-deoxy-5'-[N-methyl-N-[(2-aminooxy)-ethyl]amino]adenosine	-	Trypanosoma brucei
4.1.1.50	CGP48664A	i.e. 4-amidinoindan-1-one-2'-amidinohydrazone	Aquifex aeolicus
4.1.1.50	CGP48664A	i.e. 4-amidinoindan-1-one-2'-amidinohydrazone	Homo sapiens
4.1.1.50	CGP48664A	i.e. 4-amidinoindan-1-one-2'-amidinohydrazone	Solanum tuberosum
4.1.1.50	CGP48664A	i.e. 4-amidinoindan-1-one-2'-amidinohydrazone	Thermotoga maritima
4.1.1.50	CGP48664A	i.e. 4-amidinoindan-1-one-2'-amidinohydrazone	Trypanosoma brucei
4.1.1.50	methylglyoxalbis(guanylhydrazone)	-	Aquifex aeolicus
4.1.1.50	methylglyoxalbis(guanylhydrazone)	-	Homo sapiens
4.1.1.50	methylglyoxalbis(guanylhydrazone)	-	Solanum tuberosum
4.1.1.50	methylglyoxalbis(guanylhydrazone)	-	Thermotoga maritima
4.1.1.50	methylglyoxalbis(guanylhydrazone)	-	Trypanosoma brucei

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.1.1.50	Aquifex aeolicus	O66615	-	-
4.1.1.50	Homo sapiens	P17707	-	-
4.1.1.50	Solanum tuberosum	Q04694	-	-
4.1.1.50	Thermotoga maritima	Q9WZC3	-	-
4.1.1.50	Trypanosoma brucei	-	-	-

Posttranslational Modification

EC Number	Posttranslational Modification	Comment	Organism
4.1.1.50	additional information	AdoMetDC is expressed as an inactive proenzyme that undergoes autoprocessing to the active enzyme. The autoprocessing involves an internal serinolysis reaction leading to the cleavage of the backbone to alpha and beta subunits with the latter being the smaller subunit and to generation of a pyruvoyl group at the N-terminus of the alpha chain	Trypanosoma brucei
4.1.1.50	additional information	AdoMetDC is expressed as an inactive proenzyme that undergoes autoprocessing to the active enzyme. The autoprocessing involves an internal serinolysis reaction leading to the cleavage of the backbone to alpha and beta subunits with the latter being the smaller subunit and to generation of a pyruvoyl group at the N-terminus of the alpha chain	Homo sapiens
4.1.1.50	additional information	AdoMetDC is expressed as an inactive proenzyme that undergoes autoprocessing to the active enzyme. The autoprocessing involves an internal serinolysis reaction leading to the cleavage of the backbone to alpha and beta subunits with the latter being the smaller subunit and to generation of a pyruvoyl group at the N-terminus of the alpha chain	Thermotoga maritima
4.1.1.50	additional information	AdoMetDC is expressed as an inactive proenzyme that undergoes autoprocessing to the active enzyme. The autoprocessing involves an internal serinolysis reaction leading to the cleavage of the backbone to alpha and beta subunits with the latter being the smaller subunit and to generation of a pyruvoyl group at the N-terminus of the alpha chain	Solanum tuberosum
4.1.1.50	additional information	AdoMetDC is expressed as an inactive proenzyme that undergoes autoprocessing to the active enzyme. The autoprocessing involves an internal serinolysis reaction leading to the cleavage of the backbone to alpha and beta subunits with the latter being the smaller subunit and to generation of a pyruvoyl group at the N-terminus of the alpha chain	Aquifex aeolicus

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
4.1.1.50	S-adenosyl-L-methionine	-	Trypanosoma brucei	(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2	-	?
4.1.1.50	S-adenosyl-L-methionine	-	Homo sapiens	(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2	-	?
4.1.1.50	S-adenosyl-L-methionine	-	Thermotoga maritima	(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2	-	?
4.1.1.50	S-adenosyl-L-methionine	-	Solanum tuberosum	(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2	-	?
4.1.1.50	S-adenosyl-L-methionine	-	Aquifex aeolicus	(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2	-	?

Subunits

EC Number	Subunits	Comment	Organism
4.1.1.50	dimer	x-ray crystallography	Trypanosoma brucei
4.1.1.50	dimer	x-ray crystallography	Homo sapiens
4.1.1.50	dimer	x-ray crystallography	Thermotoga maritima
4.1.1.50	dimer	x-ray crystallography	Solanum tuberosum
4.1.1.50	dimer	x-ray crystallography	Aquifex aeolicus

Synonyms

EC Number	Synonyms	Comment	Organism
4.1.1.50	AdoMetDC	-	Trypanosoma brucei
4.1.1.50	AdoMetDC	-	Homo sapiens
4.1.1.50	AdoMetDC	-	Thermotoga maritima
4.1.1.50	AdoMetDC	-	Solanum tuberosum
4.1.1.50	AdoMetDC	-	Aquifex aeolicus
4.1.1.50	S-Adenosylmethionine decarboxylase	-	Trypanosoma brucei
4.1.1.50	S-Adenosylmethionine decarboxylase	-	Homo sapiens
4.1.1.50	S-Adenosylmethionine decarboxylase	-	Thermotoga maritima
4.1.1.50	S-Adenosylmethionine decarboxylase	-	Solanum tuberosum
4.1.1.50	S-Adenosylmethionine decarboxylase	-	Aquifex aeolicus

Cofactor

EC Number	Cofactor	Comment	Organism
4.1.1.50	pyridoxal 5'-phosphate	-	Trypanosoma brucei
4.1.1.50	pyridoxal 5'-phosphate	-	Homo sapiens
4.1.1.50	pyridoxal 5'-phosphate	-	Thermotoga maritima
4.1.1.50	pyridoxal 5'-phosphate	-	Solanum tuberosum
4.1.1.50	pyridoxal 5'-phosphate	-	Aquifex aeolicus
4.1.1.50	thiamine diphosphate	-	Trypanosoma brucei
4.1.1.50	thiamine diphosphate	-	Homo sapiens
4.1.1.50	thiamine diphosphate	-	Thermotoga maritima
4.1.1.50	thiamine diphosphate	-	Solanum tuberosum
4.1.1.50	thiamine diphosphate	-	Aquifex aeolicus