EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.154 | clomiphene | interacts with heme, is less potent than azoles | Mycobacterium tuberculosis | |
1.14.14.154 | fluconazole | - |
Mycobacterium tuberculosis | |
1.14.14.154 | glafenine | interacts with heme, shows no potency which may arise from its hydrophilic nature which lower its up-take and capacity to reach the target enzyme | Mycobacterium tuberculosis | |
1.14.14.154 | ketoconazole | residues lining the ketoconazole pocket include Ala397 and Ala398, Arg389 and Arg393, Asp377, Glu308, Gly390, Ile401, Leu311 and Leu315, Lys312, Phe387, Pro386, Trp382 and Trp384 | Mycobacterium tuberculosis | |
1.14.14.154 | miconazole | - |
Mycobacterium tuberculosis | |
1.14.14.154 | additional information | the aromatic moieties of drugs where aligning to phenylalanine and tyrosine residues that lines the hydrophobic part of the binding pocket which is itself generally hydrophobic | Mycobacterium tuberculosis | |
1.14.14.154 | N-{2-[4-(acetylamino)phenyl]ethyl}-2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetamide | interacts with heme | Mycobacterium tuberculosis | |
1.14.14.154 | rottlerin | interacts with heme | Mycobacterium tuberculosis | |
1.14.14.154 | SPSM1 | interacts with heme | Mycobacterium tuberculosis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.154 | Mycobacterium tuberculosis | P9WPP9 | - |
- |
1.14.14.154 | Mycobacterium tuberculosis H37Rv | P9WPP9 | - |
- |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.14.154 | 14alpha-lanosterol demethylase | - |
Mycobacterium tuberculosis |
1.14.14.154 | CYP51 | - |
Mycobacterium tuberculosis |