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Literature summary extracted from

  • Chitnumsub, P.; Yuvaniyama, J.; Chahomchuen, T.; Vilaivan, T.; Yuthavong, Y.
    Crystallization and preliminary crystallographic studies of dihydrofolate reductase-thymidylate synthase from Trypanosoma cruzi, the Chagas disease pathogen (2009), Acta Crystallogr. Sect. F, 65, 1175-1178.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.45 expressed in Escherichia coli BL21(DE3) cells Trypanosoma cruzi

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.1.1.45 in complexes with the dihydrotriazine-based or quinazoline-based antifolates C-448, cycloguanil, and Q-8, microbatch method, using 0.1-0.2 M ammonium acetate, 20-22% (w/v) PEG 4000 and 0.1 M sodium citrate buffer pH 5.6 Trypanosoma cruzi

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.45 58800
-
calculated from amino acid sequence Trypanosoma cruzi

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.45 Trypanosoma cruzi
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.45 methotrexate affinity column chromatography Trypanosoma cruzi

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
Trypanosoma cruzi dihydrofolate + dTMP
-
?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.45 DHFR-TS
-
Trypanosoma cruzi
2.1.1.45 dihydrofolate reductase-thymidylate synthase
-
Trypanosoma cruzi

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.45 N5,N10-methylenetetrahydrofolate
-
Trypanosoma cruzi