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Literature summary extracted from

  • Kollock, R.; Frank, H.; Seidel, A.; Meinl, W.; Glatt, H.
    Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases (2008), Toxicology, 245, 65-75.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.1 4-Methylpyrazole
-
 Homo sapiens
1.1.1.1 DMSO DMSO inhibits isozyme ADH2-catalysed oxidation in an uncompetitive mode and reduction in a mixed mode; DMSO inhibits isozymes ADH1C-catalysed oxidation in an uncompetitive mode and reduction in a mixed mode, no inhibition is detected with isozyme ADH3; DMSO inhibits isozymes ADH4-catalysed oxidation in an uncompetitive mode and reduction in a mixed mode Homo sapiens
1.1.1.1 ethanol ethanol competitively inhibits the oxidation of 1-hydroxymethylpyrene by ADH1C and ADH3; ethanol competitively inhibits the oxidation of 1-hydroxymethylpyrene by ADH4 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.1 0.000035
-
 1-formyl-8-methylpyrene isozyme ADH4, at 21-23°C Homo sapiens
1.1.1.1 0.000036
-
 1-formyl-6-methylpyrene isozyme ADH4, at 21-23°C Homo sapiens
1.1.1.1 0.00024
-
 1-formyl-8-methylpyrene isozyme ADH2, at 21-23°C Homo sapiens
1.1.1.1 0.00028
-
 1-hydroxymethyl-6-methylpyrene isozyme ADH4, at 21-23°C Homo sapiens
1.1.1.1 0.00031
-
 1-hydroxymethyl-8-methylpyrene isozyme ADH3, at 21-23°C Homo sapiens
1.1.1.1 0.00032
-
 1-formyl-6-methylpyrene isozyme ADH2, at 21-23°C Homo sapiens
1.1.1.1 0.00037
-
 4-hydroxymethylpyrene isozyme ADH3, at 21-23°C Homo sapiens
1.1.1.1 0.00048
-
 2-hydroxymethylpyrene isozyme ADH1C, at 21-23°C Homo sapiens
1.1.1.1 0.00048
-
 4-formylpyrene isozyme ADH4, at 21-23°C Homo sapiens
1.1.1.1 0.0005
-
 1-formylpyrene isozyme ADH1C, at 21-23°C Homo sapiens
1.1.1.1 0.00055
-
 1-formylpyrene isozyme ADH3, at 21-23°C Homo sapiens
1.1.1.1 0.00057
-
 1-hydroxymethyl-6-methylpyrene isozyme ADH3, at 21-23°C Homo sapiens
1.1.1.1 0.00059
-
 1-hydroxymethylpyrene isozyme ADH3, at 21-23°C Homo sapiens
1.1.1.1 0.00075
-
 1-hydroxymethylpyrene isozyme ADH1C, at 21-23°C Homo sapiens
1.1.1.1 0.0009
-
 1-formyl-6-methylpyrene isozyme ADH1C, at 21-23°C Homo sapiens
1.1.1.1 0.00092
-
 1-formylpyrene isozyme ADH4, at 21-23°C Homo sapiens
1.1.1.1 0.001
-
 4-formylpyrene isozyme ADH1C, at 21-23°C Homo sapiens
1.1.1.1 0.001
-
 4-hydroxymethylpyrene isozyme ADH1C, at 21-23°C Homo sapiens
1.1.1.1 0.00115
-
 1-hydroxymethyl-6-methylpyrene isozyme ADH1C, at 21-23°C Homo sapiens
1.1.1.1 0.00131
-
 1-formyl-8-methylpyrene isozyme ADH1C, at 21-23°C Homo sapiens
1.1.1.1 0.00149
-
 1-formyl-8-methylpyrene isozyme ADH3, at 21-23°C Homo sapiens
1.1.1.1 0.0016
-
 1-hydroxymethyl-8-methylpyrene isozyme ADH4, at 21-23°C Homo sapiens
1.1.1.1 0.0021
-
 2-formylpyrene isozyme ADH1C, at 21-23°C Homo sapiens
1.1.1.1 0.0021
-
 4-formylpyrene isozyme ADH3, at 21-23°C Homo sapiens
1.1.1.1 0.0029
-
 2-formylpyrene isozyme ADH2, at 21-23°C Homo sapiens
1.1.1.1 0.0029
-
 4-hydroxymethylpyrene isozyme ADH4, at 21-23°C Homo sapiens
1.1.1.1 0.0038
-
 4-formylpyrene isozyme ADH2, at 21-23°C Homo sapiens
1.1.1.1 0.0038
-
 1-formyl-6-methylpyrene isozyme ADH3, at 21-23°C Homo sapiens
1.1.1.1 0.0044
-
 2-hydroxymethylpyrene isozyme ADH2, at 21-23°C Homo sapiens
1.1.1.1 0.0064
-
 1-hydroxymethyl-6-methylpyrene isozyme ADH2, at 21-23°C Homo sapiens
1.1.1.1 0.0064
-
 1-hydroxymethyl-8-methylpyrene isozyme ADH2, at 21-23°C Homo sapiens
1.1.1.1 0.0069
-
 2-formylpyrene isozyme ADH4, at 21-23°C Homo sapiens
1.1.1.1 0.009
-
 2-formylpyrene isozyme ADH3, at 21-23°C Homo sapiens
1.1.1.1 0.012
-
 1-formylpyrene isozyme ADH2, at 21-23°C Homo sapiens
1.1.1.1 0.0283
-
 1-hydroxymethylpyrene isozyme ADH4, at 21-23°C Homo sapiens
1.1.1.1 0.033
-
 2-hydroxymethylpyrene isozyme ADH4, at 21-23°C Homo sapiens
1.1.1.1 0.04
-
 4-hydroxymethylpyrene isozyme ADH2, at 21-23°C Homo sapiens
1.1.1.1 0.059
-
 1-hydroxymethyl-8-methylpyrene isozyme ADH1C, at 21-23°C Homo sapiens
1.1.1.1 0.076
-
 1-hydroxymethylpyrene isozyme ADH2, at 21-23°C Homo sapiens
1.1.1.1 0.106
-
 2-hydroxymethylpyrene isozyme ADH3, at 21-23°C Homo sapiens
1.1.1.1 0.34
-
 acetaldehyde isozyme ADH1C, at 21-23°C Homo sapiens
1.1.1.1 0.39
-
 1-Octanol isozyme ADH3, at 21-23°C Homo sapiens
1.1.1.1 0.77
-
 ethanol isozyme ADH1C, at 21-23°C Homo sapiens
1.1.1.1 3.6
-
 ethanol isozyme ADH4, at 21-23°C Homo sapiens
1.1.1.1 9.6
-
 octanal isozyme ADH3, at 21-23°C Homo sapiens
1.1.1.1 12.7
-
 acetaldehyde isozyme ADH4, at 21-23°C Homo sapiens
1.1.1.1 26
-
 acetaldehyde isozyme ADH2, at 21-23°C Homo sapiens
1.1.1.1 33
-
 ethanol isozyme ADH2, at 21-23°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.1 cytosol
-
 Homo sapiens 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.1 39500
-
 isozyme ADH3, apparent molecular weight deduced from electrophoretic mobility Homo sapiens
1.1.1.1 39720
-
 isozyme ADH3, calculated from amino acid sequence Homo sapiens
1.1.1.1 39870
-
 isozyme ADH1C, calculated from amino acid sequence Homo sapiens
1.1.1.1 40000
-
 isozyme ADH2, apparent molecular weight deduced from electrophoretic mobility Homo sapiens
1.1.1.1 40000
-
 isozyme ADH4, calculated from amino acid sequence Homo sapiens
1.1.1.1 40220
-
 isozyme ADH2, calculated from amino acid sequence Homo sapiens
1.1.1.1 40500
-
 isozyme ADH1C, apparent molecular weight deduced from electrophoretic mobility Homo sapiens
1.1.1.1 40500
-
 isozyme ADH4, apparent molecular weight deduced from electrophoretic mobility Homo sapiens

Organic Solvent Stability

EC Number Organic Solvent Comment Organism
1.1.1.1 DMSO DMSO is not an ideal substrate-delivering solvent for ADH-catalysed reactions Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.1 Homo sapiens P00326
-
-
1.1.1.1 Homo sapiens P08319
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.1 buccal mucosa isozyme ADH4 Homo sapiens
-
1.1.1.1 liver isozymes ADH1C and ADH3 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.1 1-hydroxymethyl-6-methylpyrene + NAD+
-
 Homo sapiens 1-formyl-6-methylpyrene + NADH + H+
-
 r
1.1.1.1 1-hydroxymethyl-8-methylpyrene + NAD+
-
 Homo sapiens 1-formyl-8-methylpyrene + NADH + H+
-
 r
1.1.1.1 1-hydroxymethylpyrene + NAD+
-
 Homo sapiens 1-formylpyrene + NADH + H+
-
 r
1.1.1.1 1-octanol + NAD+ substrate for isozyme ADH3 Homo sapiens octanal + NADH + H+
-
 r
1.1.1.1 2-hydroxymethylpyrene + NAD+
-
 Homo sapiens 2-formylpyrene + NADH + H+
-
 r
1.1.1.1 4-hydroxymethylpyrene + NAD+
-
 Homo sapiens 4-formylpyrene + NADH + H+
-
 r
1.1.1.1 ethanol + NAD+ substrate for isozyme ADH1C, extremely poor substrate for isozyme ADH3 Homo sapiens acetaldehyde + NADH + H+
-
 r
1.1.1.1 ethanol + NAD+ substrate for isozyme ADH2 Homo sapiens acetaldehyde + NADH + H+
-
 r
1.1.1.1 ethanol + NAD+ substrate for isozyme ADH4 Homo sapiens acetaldehyde + NADH + H+
-
 r
1.1.1.1 additional information 1-octanal is no substrate for isozyme ADH1C Homo sapiens ?
-
 ?
1.1.1.1 additional information 1-octanal is no substrate for isozyme ADH2 Homo sapiens ?
-
 ?
1.1.1.1 additional information 1-octanal is no substrate for isozyme ADH4 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.1 ADH1C isozyme Homo sapiens
1.1.1.1 ADH2 isozyme Homo sapiens
1.1.1.1 ADH3 isozyme Homo sapiens
1.1.1.1 ADH4 isozyme Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.1 NAD+
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.1 1.7
-
 ethanol isozyme ADH1C, using 1-hydroxymethylpyrene as substrate Homo sapiens
1.1.1.1 3.3
-
 ethanol isozyme ADH4, using 1-hydroxymethylpyrene as substrate Homo sapiens
1.1.1.1 1470
-
 ethanol isozyme ADH3, using 1-hydroxymethylpyrene as substrate Homo sapiens