Literature summary extracted from

  • Noland, B.W.; Newman, J.M.; Hendle, J.; Badger, J.; Christopher, J.A.; Tresser, J.; Buchanan, M.D.; Wright, T.A.; Rutter, M.E.; Sanderson, W.E.; Muller-Dieckmann, H.J.; Gajiwala, K.S.; Buchanan, S.G.
    Structural studies of Salmonella typhimurium ArnB (PmrH) aminotransferase: a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme (2002), Structure, 10, 1569-1580.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.6.1.87 hanging drop vapor diffusion method, high-resolution crystal structures are solved for two native forms and one covalently inhibited form of Salmonella typhimurium ArnB (crystal structure of ArnB aminotransferase with pyridomine 5'-phosphate, crystal structure of ArnB transferase with pyridoxal 5'-phosphate, crystal structure of ArnB aminotransferase with cycloserine and pyridoxal 5'-phosphate) Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.87 UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate Salmonella enterica subsp. enterica serovar Typhimurium lipid A modification with 4-amino-4-deoxy-L-arabinose confers on certain pathogenic bacteria, such as Salmonella, resistance to cationic antimicrobial peptides, including those derived from the innate immune system ArnB catalysis of amino group transfer from glutamic acid to the 4''-position of a UDP-linked keto-pyranose molecule to form UDP-4-amino-4-deoxy-L-arabinose represents a key step in the lipid A modification pathway UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate
-
r

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.87 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.87
-
Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.87 UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate
-
Salmonella enterica subsp. enterica serovar Typhimurium UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate
-
r
2.6.1.87 UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate lipid A modification with 4-amino-4-deoxy-L-arabinose confers on certain pathogenic bacteria, such as Salmonella, resistance to cationic antimicrobial peptides, including those derived from the innate immune system ArnB catalysis of amino group transfer from glutamic acid to the 4''-position of a UDP-linked keto-pyranose molecule to form UDP-4-amino-4-deoxy-L-arabinose represents a key step in the lipid A modification pathway Salmonella enterica subsp. enterica serovar Typhimurium UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate
-
r