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Literature summary extracted from

  • Bauman, D.R.; Bitmansour, A.D.; McDonald, J.G.; Thompson, B.M.; Liang, G.; Russell, D.W.
    25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production (2009), Proc. Natl. Acad. Sci. USA, 106, 16764-16769.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.99.38 25-hydroxycholesterol
-
 Mus musculus
1.14.99.38 Kdo2-lipid A
-
 Mus musculus
1.14.99.38 additional information incubation with LPS derived from Escherichia coli or Salmonella enterica induces CH25H mRNA Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.99.38 33000
-
 determined by SDS-PAGE and Western Blot analysis Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.38 cholesterol + AH2 + O2 Mus musculus
-
 25-hydroxycholesterol + A + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.38 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.99.38 brain
-
 Mus musculus
-
1.14.99.38 colon
-
 Mus musculus
-
1.14.99.38 heart
-
 Mus musculus
-
1.14.99.38 kidney
-
 Mus musculus
-
1.14.99.38 liver
-
 Mus musculus
-
1.14.99.38 lung
-
 Mus musculus
-
1.14.99.38 macrophage
-
 Mus musculus
-
1.14.99.38 muscle
-
 Mus musculus
-
1.14.99.38 skin
-
 Mus musculus
-
1.14.99.38 small intestine
-
 Mus musculus
-
1.14.99.38 spleen
-
 Mus musculus
-
1.14.99.38 thymus
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.38 cholesterol + AH2 + O2
-
 Mus musculus 25-hydroxycholesterol + A + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.99.38 CH25A
-
 Mus musculus
1.14.99.38 cholesterol 25-hydroxylase
-
 Mus musculus