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Literature summary extracted from

  • Bhandari, R.; Juluri, K.R.; Resnick, A.C.; Snyder, S.H.
    Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis (2008), Proc. Natl. Acad. Sci. USA, 105, 2349-2353.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.4.21 gene Ihpk1, located on chromosome 9, has 6 exons, of which exon 1 is exclusively noncoding, the start codon is located in exon 2, and the stop codon is located in exon 6, DNA and amino acid sequence determination and analysis. Expressionin MEF cell lines Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.4.21 additional information gene deletion of IP6K1 in mice leads to markedly diminished production of inositol diphosphates. Male mutant mice are sterile with defects in spermiogenesis. Mutant mice are smaller than wild-type despite normal food intake. The mutants display markedly lower circulating insulin, phenotype, overview Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.4.21 EDTA
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.4.21 cytosol
-
 Mus musculus 5829
-
2.7.4.21 nucleus
-
 Mus musculus 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.4.21 Mg2+
-
 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.21 Mus musculus
-
 gene Ihpk1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.21 ATP + 1D-myo-inositol hexakisphosphate
-
 Mus musculus ADP + diphosphoinositol pentakisphosphate + bisdiphosphoinositol tetrakisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.4.21 inositol hexakisphosphate kinase 1
-
 Mus musculus
2.7.4.21 IP6K1
-
 Mus musculus
2.7.4.21 More IP6K1 belongs to the family of inositol hexakisphosphate kinases Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.4.21 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.4.21 7.4
-
 assay at Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.4.21 ATP
-
 Mus musculus