Literature summary extracted from

Seifert, A.; Klonisch, T.; Wulfaenger, J.; Haag, F.; Dralle, H.; Langner, J.; Hoang-Vu, C.; Kehlen, A.
The cellular localization of autotaxin impacts on its biological functions in human thyroid carcinoma cells (2008), Oncol. Rep., 19, 1485-1491.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.1.4.39	transfection of FTC-238 cells with pEGFP-C3/ATX-construct for secretion of expressed ATX and with pD38tm/ATX-construct for production of membrane-anchored ATX respectively. sATX clones show higher cell motility than mATX clones (transwell filter assay), addition of interleukin-1beta to culture medium reduces cell motility due to downregulating ATX gene activity (mRNA expression level analysed by quantitative-RT-PCR), colony soft agar assay of sATX-clones results in bigger amount and bigger diameter of colonies compared to mATX-clones	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.1.4.39	lysophosphatidylcholine + H2O	Homo sapiens	lysophospholipase D activity	lysophosphatidic acid + choline	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.4.39	Homo sapiens	Q13822	-	-

Posttranslational Modification

EC Number	Posttranslational Modification	Comment	Organism
3.1.4.39	glycoprotein	-	Homo sapiens

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.4.39	lysophosphatidylcholine + H2O	lysophospholipase D activity	Homo sapiens	lysophosphatidic acid + choline	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.1.4.39	ATX	-	Homo sapiens
3.1.4.39	autotaxin	-	Homo sapiens
3.1.4.39	lysophospholipase D	-	Homo sapiens
3.1.4.39	NPP2	-	Homo sapiens
3.1.4.39	nucleotide phosphodiesterase/pyrophosphatase (NPP)	-	Homo sapiens

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Release 2023.1 (January 2023)