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Literature summary extracted from

  • Acharya, J.K.; Dasgupta, U.; Rawat, S.S.; Yuan, C.; Sanxaridis, P.D.; Yonamine, I.; Karim, P.; Nagashima, K.; Brodsky, M.H.; Tsunoda, S.; Acharya, U.
    Cell-nonautonomous function of ceramidase in photoreceptor homeostasis (2008), Neuron, 57, 69-79.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.23 CDase specific RNAi
-
Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.23 endosome
-
Drosophila melanogaster 5768
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.23 ceramide + H2O Drosophila melanogaster
-
sphingosine + fatty acid
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.23 Drosophila melanogaster Q9VA70
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.23 retina
-
Drosophila melanogaster
-
3.5.1.23 S2 cell
-
Drosophila melanogaster
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.1.23 0.00052
-
control w1118 fly Drosophila melanogaster
3.5.1.23 0.00125
-
CDase null mutant and CDase null expressing fat body driven CDase Drosophila melanogaster

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.23 C12-4-nitrobenzo-2-oxa-1,3-diazole-ceramide + H2O substrate activity assay Drosophila melanogaster ?
-
?
3.5.1.23 ceramide + H2O
-
Drosophila melanogaster sphingosine + fatty acid
-
?
3.5.1.23 palmitoyl sphingosine + H2O substrate activity assay Drosophila melanogaster palmitate + sphingosine
-
?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.23 CDase
-
Drosophila melanogaster
3.5.1.23 ceramidase
-
Drosophila melanogaster
3.5.1.23 neutral ceramidase
-
Drosophila melanogaster