EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.4.1.4 | ATP | 30% stimulation in the presence of 2 mM Mg2+ | Aspergillus terreus | |
1.4.1.4 | GDP | 30% stimulation in the presence of 2 mM Mg2+ | Aspergillus terreus | |
1.4.1.4 | GTP | 30% stimulation in the presence of 2 mM Mg2+ | Aspergillus terreus |
EC Number | General Stability | Organism |
---|---|---|
1.4.1.4 | after incubation with chymotrypsin enzyme loses 50% activity within 30 min and a combination of 2-oxoglutarate and NADP+ affords near complete protection against chymotrypsin | Aspergillus niger |
1.4.1.4 | Aspergillus terreus NADP-GDH remains fully active even after 2 h of incubation with chymotrypsin | Aspergillus terreus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.4.1.4 | 2,4-pyridinedicarboxylate | weak inhibitor | Aspergillus terreus | |
1.4.1.4 | 2-Methyleneglutarate | weak inhibitor | Aspergillus terreus | |
1.4.1.4 | isophthalate | weak inhibitor | Aspergillus terreus | |
1.4.1.4 | NH4+ | inhibits the oxidative deamination activity as a product, inhibition is non-competitive with respect to L-glutamate | Aspergillus terreus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.4.1.4 | 0.011 | - |
NADPH | 28°C | Aspergillus niger | |
1.4.1.4 | 0.017 | - |
NADP+ | 28°C | Aspergillus niger | |
1.4.1.4 | 0.045 | - |
NADP+ | 28°C | Aspergillus terreus | |
1.4.1.4 | 0.055 | - |
NADPH | 28°C | Aspergillus terreus | |
1.4.1.4 | 0.95 | - |
NH4+ | 28°C | Aspergillus terreus | |
1.4.1.4 | 1.05 | - |
NH4+ | 28°C | Aspergillus niger | |
1.4.1.4 | 4.78 | - |
2-oxoglutarate | 28°C | Aspergillus niger | |
1.4.1.4 | 6 | - |
2-oxoglutarate | 28°C | Aspergillus terreus | |
1.4.1.4 | 24.1 | - |
L-glutamate | 28°C | Aspergillus terreus | |
1.4.1.4 | 34.6 | - |
L-glutamate | 28°C | Aspergillus niger |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.4.1.4 | Mg2+ | - |
Aspergillus terreus | |
1.4.1.4 | Zn2+ | forward reaction of GDH from Aspergillus terreus is 80% inhibited by 5 mM ZnCl2 | Aspergillus terreus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.4.1.4 | 50000 | - |
SDS-PAGE | Aspergillus terreus |
1.4.1.4 | 350000 | - |
FPLC on a Superdex G-75 column | Aspergillus terreus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.4.1.4 | Aspergillus niger | - |
GDH from Aspergillus terreus is kinetically distinct from GDH of Aspergilli niger | - |
1.4.1.4 | Aspergillus terreus | - |
GDH from Aspergillus terreus is kinetically distinct from GDH of Aspergilli niger | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.4.1.4 | purified to homogeneity using novel reactive dye-affinity resins | Aspergillus niger |
1.4.1.4 | purified to homogeneity using novel reactive dye-affinity resins | Aspergillus terreus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.4.1.4 | 2-oxoglutarate + NH4+ + NADPH | - |
Aspergillus niger | L-glutamate + NADP+ | - |
? | |
1.4.1.4 | 2-oxoglutarate + NH4+ + NADPH | - |
Aspergillus terreus | L-glutamate + NADP+ | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.4.1.4 | hexamer | - |
Aspergillus niger |
1.4.1.4 | hexamer | 6 x 50000, SDS-PAGE | Aspergillus terreus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.4.1.4 | NADP-glutamate dehydrogenase | - |
Aspergillus niger |
1.4.1.4 | NADP-glutamate dehydrogenase | - |
Aspergillus terreus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.4.1.4 | 28 | - |
assay at | Aspergillus niger |
1.4.1.4 | 28 | - |
assay at | Aspergillus terreus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.4.1.4 | 8 | - |
reductive amination | Aspergillus terreus |
1.4.1.4 | 9.5 | - |
oxidative deamination | Aspergillus terreus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.4.1.4 | NADPH | specifically used | Aspergillus niger | |
1.4.1.4 | NADPH | specifically used | Aspergillus terreus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.4.1.4 | 0.17 | - |
NH4+ | - |
Aspergillus terreus |