Literature summary extracted from

Long, K.S.; Poehlsgaard, J.; Hansen, L.H.; Hobbie, S.N.; Boettger, E.C.; Vester, B.
Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket (2009), Mol. Microbiol., 71, 1218-1227.

Protein Variants

EC Number	Protein Variants	Comment	Organism
2.3.2.12	additional information	introduction of individual 23S rRNA mutations associated with pleuromutilin resistance at positions 2055, 2447, 2504 and 2572, Escherichia coli numbering, into a Mycobacterium smegmatis strain with a single rRNA operon. The single mutations each confer a significant and similar degree of valnemulin resistance and those at 2447 and 2504 also confer cross-resistance to other antibiotics that bind to the peptidyl transfer center. The introduced mutations cause structural perturbations at the peptidyl transfer center and reduce binding of pleuromutilin antibiotics	Mycolicibacterium smegmatis

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.3.2.12	valnemulin	single mutations at positions 2055, 2447, 2504 and 2572, Escherichia coli numbering, of 23S rRNA each confer a significant and similar degree of valnemulin resistance	Mycolicibacterium smegmatis

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.2.12	Mycolicibacterium smegmatis	-	-	-

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Release 2023.1 (January 2023)