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Literature summary extracted from

  • Wallrath, L.; Elgin, S.
    Stimulating conversations between HP1a and histone demethylase dKDM4A (2008), Mol. Cell, 32, 601-602.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.11.69 heterochromatin protein 1 predominant localization to centric heterochromatin. HP1a, when resident near centromeres, plays a role in the gene silencing associated with heterochromatin packaging. HP1a binding, two molecules HP1a per enzyme molecule, stimulates demethylation of H3K36me2 and H3K36me3 by dKDM4a, mechanism, overview. HP1a mutant V26M is inactive Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.69 [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 Drosophila melanogaster JmjC domain-containing protein dKDM4A is a histone H3K36 demethylase. Histone H3 methylation is one of the consistent marks distinguishing alternative chromatin packaging states [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.69 Drosophila melanogaster
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-
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.69 [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2
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 Drosophila melanogaster [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
1.14.11.69 [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 JmjC domain-containing protein dKDM4A is a histone H3K36 demethylase. Histone H3 methylation is one of the consistent marks distinguishing alternative chromatin packaging states Drosophila melanogaster [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2
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 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.69 dKDM4A
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 Drosophila melanogaster
1.14.11.69 H3K36 histone demethylase
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 Drosophila melanogaster