Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Lee, N.; Erdjument-Bromage, H.; Tempst, P.; Jones, R.S.; Zhang, Y.
    The H3K4 demethylase lid associates with and inhibits histone deacetylase Rpd3 (2009), Mol. Cell. Biol., 29, 1401-1410.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.11.67 ascorbate required Drosophila melanogaster

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.11.67 overexpression of Flag-tagged Mrg15, CG13367, and Lid in S2 cells Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.11.67 nucleus Lid-containing protein complex, which is composed of proteins Lid, Rpd3, CG3815/Drosophila Pf1, CG13367, and Mrg15 Drosophila melanogaster 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.67 Fe2+ required Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.67 additional information Drosophila melanogaster the demethylase activity of Lid is not affected by its association with other proteins, but Lid antagonizes Rpd3 function acting as a positive trancription regulator. Lid inhibits the activity of Rpd3 at an Rpd3 target gene ?
-
 ?
1.14.11.67 [histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 Drosophila melanogaster
-
 [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.67 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.67 embryo
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.67 additional information the demethylase activity of Lid is not affected by its association with other proteins, but Lid antagonizes Rpd3 function acting as a positive trancription regulator. Lid inhibits the activity of Rpd3 at an Rpd3 target gene Drosophila melanogaster ?
-
 ?
1.14.11.67 [histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2
-
 Drosophila melanogaster [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.14.11.67 More Lid is organized in a protein complex, which is composed of proteins Lid, Rpd3, CG3815/Drosophila Pf1, CG13367, and Mrg15, overview Drosophila melanogaster

Synonyms

EC Number Synonyms Comment Organism
1.14.11.67 H3K4 demethylase
-
 Drosophila melanogaster
1.14.11.67 histone H3 lysine 4 demethylase
-
 Drosophila melanogaster
1.14.11.67 Lid
-
 Drosophila melanogaster
1.14.11.67 little imaginal discs
-
 Drosophila melanogaster
1.14.11.67 More the enzyme is a Trithorax group protein belonging to the JmjC domain-containing proteins Drosophila melanogaster

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.11.67 30
-
 assay at Drosophila melanogaster

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.11.67 7.9
-
 assay at Drosophila melanogaster

General Information

EC Number General Information Comment Organism
1.14.11.67 physiological function function of Lid in gene activation, the biochemical activity of this protein entails the removal of a histone mark that is correlated with active transcription Drosophila melanogaster