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Literature summary extracted from
- Synthesis of the phosphinic analogue of thyrotropin releasing hormone (2008), J. Org. Chem., 73, 8591-8593.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.19.6 | medicine | pyroglutamyl peptidase II inhibitors may be used to enhance the therapeutic actions of thyrotropin releasing hormone | Mammalia |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.19.6 | Glp-PSI[P(O)(OH)CH2]-His-Pro-NH2 | phosphinic analogue of thyrotropin releasing hormone, ED50 170 nM | Mammalia |  |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.19.6 | Zn2+ | - |
Mammalia | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.19.6 | Mammalia | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.19.6 | thyrotropin releasing hormone + H2O | - |
Mammalia | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.19.6 | PPII | - |
Mammalia |
| 3.4.19.6 | pyroglutamyl peptidase II | - |
Mammalia |
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