Literature summary extracted from

Cordoba, E.; Salmi, M.; Leon, P.
Unravelling the regulatory mechanisms that modulate the MEP pathway in higher plants (2009), J. Exp. Bot., 60, 2933-2943.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.1.1.267	additional information	transcript accumulation of DXR gene is regulated by mechanical wounding and fungal elicitors. Expression of the DXR gene in rubber trees is not induced by light	Hevea brasiliensis

EC Number	Application	Comment	Organism
1.1.1.267	biotechnology	DXR plays a role in the methyl-D-erythritol 4-phosphate pathway, which is responsible for the biosynthesis of a substantial number of natural compounds of biological and biotechnological importance and is considered as a target to develop new herbicides and antimicrobial drugs	Hevea brasiliensis

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.267	Hevea brasiliensis	-	-	-
2.2.1.7	Arabidopsis thaliana	Q38854	-	-
2.2.1.7	Escherichia coli	-	-	-
2.2.1.7	Ginkgo biloba	-	-	-
2.2.1.7	Medicago truncatula	Q8L692	-	-
2.2.1.7	Medicago truncatula	Q8L693	-	-
2.2.1.7	Oryza sativa	-	-	-
2.2.1.7	Picea abies	A7LA00	-	-
2.2.1.7	Picea abies	A7LA01	-	-
2.2.1.7	Picea abies	A7LA02	-	-
2.2.1.7	Solanum lycopersicum	-	-	-
2.2.1.7	Solanum tuberosum	-	-	-
2.2.1.7	Zea mays	-	-	-

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.267	additional information	RIF10 and RIF1 mutants with defects in plastid RNA processing, protein accumulation, and protein degradation, accumulate higher levels of DXR	Hevea brasiliensis	-

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
1.1.1.267	1-deoxy-D-xylulose 5-phosphate + NAD(P)H + H+	-	Hevea brasiliensis	2-C-methyl-D-erythritol 4-phosphate + NAD(P)+	-	?
1.1.1.267	additional information	DXR has rate-limiting roles in isopentenyl diphosphate and dimethylallyl diphosphate synthesis	Hevea brasiliensis	?	-	?
2.2.1.7	pyruvate + glyceraldehyde 3-phosphate	-	Escherichia coli	1-deoxy-D-xylulose 5-phosphate + CO2	-	?
2.2.1.7	pyruvate + glyceraldehyde 3-phosphate	-	Zea mays	1-deoxy-D-xylulose 5-phosphate + CO2	-	?
2.2.1.7	pyruvate + glyceraldehyde 3-phosphate	-	Solanum tuberosum	1-deoxy-D-xylulose 5-phosphate + CO2	-	?
2.2.1.7	pyruvate + glyceraldehyde 3-phosphate	-	Solanum lycopersicum	1-deoxy-D-xylulose 5-phosphate + CO2	-	?
2.2.1.7	pyruvate + glyceraldehyde 3-phosphate	-	Oryza sativa	1-deoxy-D-xylulose 5-phosphate + CO2	-	?
2.2.1.7	pyruvate + glyceraldehyde 3-phosphate	-	Ginkgo biloba	1-deoxy-D-xylulose 5-phosphate + CO2	-	?
2.2.1.7	pyruvate + glyceraldehyde 3-phosphate	-	Picea abies	1-deoxy-D-xylulose 5-phosphate + CO2	-	?
2.2.1.7	pyruvate + glyceraldehyde 3-phosphate	-	Medicago truncatula	1-deoxy-D-xylulose 5-phosphate + CO2	-	?
2.2.1.7	pyruvate + glyceraldehyde 3-phosphate	-	Arabidopsis thaliana	1-deoxy-D-xylulose 5-phosphate + CO2	-	?

EC Number	Synonyms	Comment	Organism
1.1.1.267	DXP reductoisomerase	-	Hevea brasiliensis
1.1.1.267	DXR	-	Hevea brasiliensis
1.1.1.267	DXR1	-	Hevea brasiliensis
2.2.1.7	1-deoxy-D-xylulose-5-phosphate synthase	-	Escherichia coli
2.2.1.7	1-deoxy-D-xylulose-5-phosphate synthase	-	Zea mays
2.2.1.7	1-deoxy-D-xylulose-5-phosphate synthase	-	Solanum tuberosum
2.2.1.7	1-deoxy-D-xylulose-5-phosphate synthase	-	Solanum lycopersicum
2.2.1.7	1-deoxy-D-xylulose-5-phosphate synthase	-	Oryza sativa
2.2.1.7	1-deoxy-D-xylulose-5-phosphate synthase	-	Ginkgo biloba
2.2.1.7	1-deoxy-D-xylulose-5-phosphate synthase	-	Picea abies
2.2.1.7	1-deoxy-D-xylulose-5-phosphate synthase	-	Medicago truncatula
2.2.1.7	1-deoxy-D-xylulose-5-phosphate synthase	-	Arabidopsis thaliana
2.2.1.7	DXS	-	Escherichia coli
2.2.1.7	DXS	-	Zea mays
2.2.1.7	DXS	-	Solanum tuberosum
2.2.1.7	DXS	-	Solanum lycopersicum
2.2.1.7	DXS	-	Oryza sativa
2.2.1.7	DXS	-	Ginkgo biloba
2.2.1.7	DXS	-	Picea abies
2.2.1.7	DXS	-	Medicago truncatula
2.2.1.7	DXS	-	Arabidopsis thaliana
2.2.1.7	DXS1	-	Zea mays
2.2.1.7	DXS1	-	Arabidopsis thaliana
2.2.1.7	DXS2	-	Zea mays
2.2.1.7	DXS2	-	Arabidopsis thaliana
2.2.1.7	DXS3	-	Arabidopsis thaliana
2.2.1.7	GbDXS1	-	Ginkgo biloba
2.2.1.7	GbDXS2	-	Ginkgo biloba
2.2.1.7	MtDXS1	-	Medicago truncatula
2.2.1.7	MtDXS2	-	Medicago truncatula
2.2.1.7	OsDXS1	-	Oryza sativa
2.2.1.7	OsDXS2	-	Oryza sativa
2.2.1.7	OsDXS3	-	Oryza sativa
2.2.1.7	PaDXS1	-	Picea abies
2.2.1.7	PaDXS2A	-	Picea abies
2.2.1.7	PaDXS2B	-	Picea abies

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.267	NAD(P)H	-	Hevea brasiliensis

EC Number	General Information	Comment	Organism
2.2.1.7	malfunction	knockout mutations with lethal albino plants	Arabidopsis thaliana
2.2.1.7	physiological function	first enzyme of the methyl-D-erythritol 4-phsophate pathway in plants, influence on isoprenoid synthesis	Zea mays
2.2.1.7	physiological function	first enzyme of the methyl-D-erythritol 4-phsophate pathway in plants, influence on isoprenoid synthesis	Solanum lycopersicum
2.2.1.7	physiological function	first enzyme of the methyl-D-erythritol 4-phsophate pathway in plants, influence on isoprenoid synthesis	Oryza sativa
2.2.1.7	physiological function	first enzyme of the methyl-D-erythritol 4-phsophate pathway in plants, influence on isoprenoid synthesis	Ginkgo biloba
2.2.1.7	physiological function	first enzyme of the methyl-D-erythritol 4-phsophate pathway in plants, influence on isoprenoid synthsese	Solanum tuberosum
2.2.1.7	physiological function	first enzyme of the methyl-D-erythritol 4-phsophate pathway in plants, influence on isoprenoid synthsese	Picea abies
2.2.1.7	physiological function	first enzyme of the methyl-D-erythritol 4-phsophate pathway in plants, influence on isoprenoid synthsese	Medicago truncatula
2.2.1.7	physiological function	first enzyme of the methyl-D-erythritol 4-phsophate pathway in plants, influence on isoprenoid synthsese	Arabidopsis thaliana
2.2.1.7	physiological function	required for the synthesis of the non-isoprenoid vitamins thiamine and pyridoxal	Escherichia coli