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Literature summary extracted from

  • Senturk, M.; Irfan Kufrevioglu, O.; Ciftci, M.
    Effects of some analgesic anaesthetic drugs on human erythrocyte glutathione reductase: an in vitro study (2009), J. Enzyme Inhib. Med. Chem., 24, 420-424.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.7 diclofenac sodium competitive inhibition Homo sapiens
1.8.1.7 etomidate competitive inhibition Homo sapiens
1.8.1.7 Ketoprofen competitive inhibition Homo sapiens
1.8.1.7 lornoxicam competitive inhibition Homo sapiens
1.8.1.7 morphine competitive inhibition Homo sapiens
1.8.1.7 propofol noncompetitive inhibition Homo sapiens
1.8.1.7 tenoxicam competitive inhibition Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.7 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.1.7 ammonium sulfate precipitation, 2',5'-ADP Sepharose 4B column chromatography and Sephadex G-200 gel filtration Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.7 erythrocyte
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.8.1.7 0.0097
-
 hemolysate, at 25°C, pH 8.0 Homo sapiens
1.8.1.7 20.75
-
 after 2139fold purification, at 25°C, pH 8.0 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.7 glutathione disulfide + NADPH + H+
-
 Homo sapiens glutathione + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.8.1.7 glutathione reductase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.7 FAD
-
 Homo sapiens
1.8.1.7 NADPH
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.8.1.7 0.0165
-
 morphine in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens
1.8.1.7 0.0725
-
 etomidate in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens
1.8.1.7 0.13
-
 tenoxicam in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens
1.8.1.7 0.418
-
 propofol in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens
1.8.1.7 0.42
-
 lornoxicam in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens
1.8.1.7 22.14
-
 Ketoprofen in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens
1.8.1.7 23.97
-
 diclofenac sodium in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.8.1.7 0.0128
-
 in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens morphine
1.8.1.7 0.0523
-
 in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens etomidate
1.8.1.7 0.082
-
 in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens tenoxicam
1.8.1.7 0.242
-
 in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens propofol
1.8.1.7 0.3
-
 in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens lornoxicam
1.8.1.7 6.278
-
 in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens Ketoprofen
1.8.1.7 7.265
-
 in 100 mM Tris-HCl buffer, pH 8.0, at 25°C Homo sapiens diclofenac sodium