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Literature summary extracted from

  • Zhuang, J.X.; Li, W.G.; Qiu, L.; Zhong, X.; Zhou, J.J.; Chen, Q.X.
    Inhibitory effects of Cefazolin and Cefodizime on the activity of mushroom tyrosinase (2009), J. Enzyme Inhib. Med. Chem., 24, 251-256.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 cefazolin reversible, competitive inhibition of both monophenolase and diphenolase activities of tyrosinase Agaricus bisporus
1.14.18.1 cefodizime reversible, mixed-type inhibition of both monophenolase and diphenolase activities of tyrosinase Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-tyrosine + O2
-
Agaricus bisporus L-DOPA + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 tyrosinase
-
Agaricus bisporus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.18.1 0.0129
-
cefodizime in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus
1.14.18.1 0.11
-
cefazolin in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.02
-
for diphenolase activity of tyrosinase, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus cefazolin
1.14.18.1 0.13
-
for monophenolase activity of tyrosinase, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus cefodizime
1.14.18.1 0.21
-
for diphenolase activity of tyrosinase, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus cefodizime
1.14.18.1 7
-
for monophenolase activity of tyrosinase, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus cefazolin