Literature summary extracted from

Gou, L.; Lu, Z.R.; Park, D.; Sang, H.; Shi, L.; Seong, J.; Bhak, J.; Park, Y.; Ren, Z.; Zou, F.
The effect of histidine residue modification on tyrosinase activity and conformation: Inhibition kinetics and computational prediction (2008), J. Biomol. Struct. Dyn., 26, 395-401.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.14.18.1	Bromoacetate	noncompetitive inhibition in a dose-dependent manner	Agaricus bisporus
1.14.18.1	additional information	histidine chemical modification of tyrosinase conspicuously inactivates enzyme activity	Agaricus bisporus

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.14.18.1	0.51	-	L-Dopa	-	Agaricus bisporus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.18.1	Agaricus bisporus	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.18.1	L-DOPA + O2	-	Agaricus bisporus	dopaquinone + H2O	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.18.1	tyrosinase	-	Agaricus bisporus

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
1.14.18.1	25	-	-	Agaricus bisporus	Bromoacetate

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Release 2023.1 (January 2023)