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Literature summary extracted from

  • Lu, C.; Lin, Y.; Yeh, S.R.
    Inhibitory substrate binding site of human indoleamine 2,3-dioxygenase (2009), J. Am. Chem. Soc., 131, 12866-12867.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.52 1-(1H-indol-3-yl)ethanol effector Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.52 1-methyl-L-tryptophan substrate inhibition, 1-methyl-D-tryptophan exhibits no inhibitory effect Homo sapiens
1.13.11.52 L-tryptophan substrate inhibition Homo sapiens
1.13.11.52 mitomycin C
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.52 0.015
-
 L-tryptophan
-
 Homo sapiens
1.13.11.52 0.015
-
 L-tryptophan in the presence of 5.1 mM 3-indole ethanol Homo sapiens
1.13.11.52 0.016
-
 L-tryptophan in the presence of 2.5 mM 3-indole ethanol Homo sapiens
1.13.11.52 0.042
-
 O2
-
 Homo sapiens
1.13.11.52 0.062
-
 1-methyl-L-tryptophan
-
 Homo sapiens
1.13.11.52 2.6
-
 D-tryptophan
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 1-methyl-L-tryptophan + O2
-
 Homo sapiens ?
-
 ?
1.13.11.52 D-tryptophan + O2
-
 Homo sapiens N-formyl-D-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2
-
 Homo sapiens N-formylkynurenine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.52 indoleamine 2,3-dioxygenase
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.13.11.52 0.064
-
 1-methyl-L-tryptophan
-
 Homo sapiens
1.13.11.52 2.9
-
 O2
-
 Homo sapiens
1.13.11.52 3.1
-
 L-tryptophan
-
 Homo sapiens
1.13.11.52 3.2
-
 L-tryptophan in the presence of 2.5 mM 3-indole ethanol Homo sapiens
1.13.11.52 3.5
-
 L-tryptophan in the presence of 5.1 mM 3-indole ethanol Homo sapiens
1.13.11.52 5.9
-
 D-tryptophan
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.13.11.52 heme
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.52 0.032
-
 1-methyl-L-tryptophan
-
 Homo sapiens