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Literature summary extracted from

  • Bandyopadhyay, P.; Jha, S.; Imran Ali, S.K.
    Picolyl alkyl amines as novel tyrosinase inhibitors: Influence of hydrophobicity and substitution (2009), J. Agric. Food Chem., 57, 9780-9786.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 alpha-picolyl heptyl amine
-
 Agaricus bisporus
1.14.18.1 alpha-picolyl nonyl amine
-
 Agaricus bisporus
1.14.18.1 alpha-picolyl pentyl amine
-
 Agaricus bisporus
1.14.18.1 alpha-picolyl propyl amine
-
 Agaricus bisporus
1.14.18.1 beta-picolyl heptyl amine uncompetitive inhibition of monophenolase and diphenolase activities Agaricus bisporus
1.14.18.1 beta-picolyl nonyl amine
-
 Agaricus bisporus
1.14.18.1 beta-picolyl pentyl amine uncompetitive inhibition of monophenolase and diphenolase activities Agaricus bisporus
1.14.18.1 beta-picolyl propyl amine uncompetitive inhibition of monophenolase and diphenolase activities Agaricus bisporus
1.14.18.1 gamma-picolyl heptyl amine uncompetitive inhibition of monophenolase activity and mixed-type inhibition of diphenolase activity Agaricus bisporus
1.14.18.1 gamma-picolyl nonyl amine
-
 Agaricus bisporus
1.14.18.1 gamma-picolyl pentyl amine uncompetitive inhibition of monophenolase activity and mixed-type inhibition of diphenolase activity Agaricus bisporus
1.14.18.1 gamma-picolyl propyl amine uncompetitive inhibition of monophenolase activity and mixed-type inhibition of diphenolase activity Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-DOPA + O2 o-diphenolase activity Agaricus bisporus dopaquinone + H2O
-
 ?
1.14.18.1 L-tyrosine + O2 o-monophenolase activity Agaricus bisporus L-DOPA + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 tyrosinase
-
 Agaricus bisporus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.18.1 18
-
 gamma-picolyl heptyl amine in 0.1 M phosphate buffer (pH 6.5) Agaricus bisporus
1.14.18.1 20
-
 gamma-picolyl pentyl amine in 0.1 M phosphate buffer (pH 6.5) Agaricus bisporus
1.14.18.1 23
-
 gamma-picolyl propyl amine in 0.1 M phosphate buffer (pH 6.5) Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 4.2
-
 in 0.1 M phosphate buffer (pH 6.5) Agaricus bisporus gamma-picolyl pentyl amine
1.14.18.1 5.8
-
 in 0.1 M phosphate buffer (pH 6.5) Agaricus bisporus gamma-picolyl propyl amine
1.14.18.1 6.8
-
-
 Agaricus bisporus gamma-picolyl heptyl amine
1.14.18.1 9.5
-
 in 0.1 M phosphate buffer (pH 6.5) Agaricus bisporus beta-picolyl heptyl amine
1.14.18.1 12
-
 IC50 above 12 mM, in 0.1 M phosphate buffer (pH 6.5) Agaricus bisporus alpha-picolyl propyl amine
1.14.18.1 12
-
 IC50 above 12 mM, in 0.1 M phosphate buffer (pH 6.5) Agaricus bisporus alpha-picolyl pentyl amine
1.14.18.1 12
-
 IC50 above 12 mM, in 0.1 M phosphate buffer (pH 6.5) Agaricus bisporus alpha-picolyl heptyl amine
1.14.18.1 12
-
 in 0.1 M phosphate buffer (pH 6.5) Agaricus bisporus beta-picolyl propyl amine
1.14.18.1 12
-
 in 0.1 M phosphate buffer (pH 6.5) Agaricus bisporus beta-picolyl pentyl amine