Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Masson, P.; Froment, M.T.; Gillon, E.; Nachon, F.; Lockridge, O.; Schopfer, L.M.
    Kinetic analysis of effector modulation of butyrylcholinesterase-catalysed hydrolysis of acetanilides and homologous esters (2008), FEBS J., 275, 2617-2631.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.1.13 N-benzyl-N-dodecyl-N,N-dimethylammonium chloride activator at high substrate concentrations Homo sapiens
3.5.1.13 tyramine activator of hydrolysis for neutral substrates Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.1.13
-
 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.5.1.13 D70G peripheral anionic site mutant Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.13 N-benzyl-N-dodecyl-N,N-dimethylammonium chloride inhibitor at low substrate concentrations Homo sapiens
3.5.1.13 serotonin
-
 Homo sapiens
3.5.1.13 tyramine inhibitor of hydrolysis for charged substrates Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.13 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.1.13
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.13 3-(acetamido)N,N,N-trimethylanilinium + H2O
-
 Homo sapiens 3-amino-N,N,N-trimethylanilinium + acetic acid
-
 ?
3.5.1.13 o-nitroacetanilide + H2O
-
 Homo sapiens 2-nitroaniline + acetic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.13 aryl acylaminidase aryl acylaminidase activity of butyrylcholinesterase Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5.1.13 0.00005
-
 N-benzyl-N-dodecyl-N,N-dimethylammonium chloride wild type, substrate: m-(acetamido)N,N,N-trimethylanilinium, inhibition depends on substrate concentration Homo sapiens
3.5.1.13 0.013
-
 N-benzyl-N-dodecyl-N,N-dimethylammonium chloride mutant D70G, substrate: m-(acetamido)N,N,N-trimethylanilinium Homo sapiens
3.5.1.13 0.09
-
 serotonin wild type, substrate: m-(acetamido)N,N,N-trimethylanilinium Homo sapiens
3.5.1.13 0.27
-
 serotonin mutant D70G, substrate: m-(acetamido)N,N,N-trimethylanilinium Homo sapiens
3.5.1.13 0.3
-
 N-benzyl-N-dodecyl-N,N-dimethylammonium chloride value above 0.3 mM, mutant D70G, substrate: o-nitroacetanilide, inhibition depends on substrate concentration Homo sapiens
3.5.1.13 0.37
-
 N-benzyl-N-dodecyl-N,N-dimethylammonium chloride wild type, substrate: o-nitroacetanilide Homo sapiens
3.5.1.13 2.4
-
 tyramine wild type, substrate: m-(acetamido)N,N,N-trimethylanilinium Homo sapiens
3.5.1.13 6.15
-
 tyramine mutant D70G, substrate: m-(acetamido)N,N,N-trimethylanilinium Homo sapiens
3.5.1.13 7.7
-
 serotonin wild type, substrate: o-nitroacetanilide Homo sapiens
3.5.1.13 7.9
-
 serotonin mutant D70G, substrate: o-nitroacetanilide Homo sapiens