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Literature summary extracted from

  • Yan, Q.; Cao, R.; Yi, W.; Chen, Z.; Wen, H.; Ma, L.; Song, H.
    Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities (2009), Eur. J. Med. Chem., 44, 4235-4243.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 4-hydroxybenzaldehyde 16.4% inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 4-methoxycinnamic acid 46.62% inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 5-(4-(2-(2-methoxyethoxy)ethoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione 97.49% inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 5-(4-(2-(2-methoxyethoxy)ethoxy)benzyl)pyrimidine-2,4,6(1H,3H,5H)trione 14.3% inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 5-(4-(2-(2-methoxyethoxy)ethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione complete inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 5-(4-(2-(2-methoxyethoxy)ethoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione 88.67% inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 5-(4-(2-butoxyethoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione 78.67% inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 5-(4-(2-butoxyethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione 85.88% inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 5-(4-(2-butoxyethoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione complete inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 5-(4-(2-hydroxyethoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione 95.86% inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 5-(4-(2-hydroxyethoxy)benzyl)pyrimidine-2,4,6(1H,3H,5H)-trione 5.27% inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 5-(4-(2-hydroxyethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione 16.54% inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 5-(4-(2-hydroxyethoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione 22.41% inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 5-(4-(2-methoxyethoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione complete inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 5-(4-(2-methoxyethoxy)benzyl)pyrimidine-2,4,6(1H,3H,5H)-trione 23.12% inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 5-(4-(2-methoxyethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione complete inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 5-(4-(2-methoxyethoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione complete inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 5-(4-(4-methoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione 12.2% inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 5-(4-(4-methoxybutoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione 9.85% inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 5-(4-(4-methoxyethoxy)benzyl)pyrimidine-2,4,6(1H,3H,5H)-trione 1.15% inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 5-(4-(4-methoxyethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione complete inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 5-(4-hydroxybenzyl)-2-thioxo-dihydropyrimidine-4,6(1H,5H)-dione complete inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 5-(4-hydroxybenzyl)pyrimidine-2,4,6(1H,3H,5H)-trione 47.5% inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 5-(4-hydroxybenzylidene)-2-thioxo-dihydropyrimidine-4,6(1H,5H)-dione complete inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 5-(4-hydroxybenzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione complete inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 Barbituric acid 5.95% inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 additional information 5-(4-(2-butoxyethoxy)benzyl)pyrimidine-2,4,6(1H,3H,5H)-trione is not active against tyrosinase Agaricus bisporus
1.14.18.1 Thiobarbituric acid 8.21% inhibition at 0.2 mM Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-DOPA + O2
-
Agaricus bisporus dopaquinone + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 tyrosinase
-
Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.01398
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 5-(4-hydroxybenzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
1.14.18.1 0.01449
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 5-(4-hydroxybenzylidene)-2-thioxo-dihydropyrimidine-4,6(1H,5H)-dione
1.14.18.1 0.02843
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 5-(4-(2-methoxyethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
1.14.18.1 0.0342
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 5-(4-(2-(2-methoxyethoxy)ethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
1.14.18.1 0.04545
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 5-(4-(2-butoxyethoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
1.14.18.1 0.07002
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 5-(4-hydroxybenzyl)-2-thioxo-dihydropyrimidine-4,6(1H,5H)-dione
1.14.18.1 0.07542
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 5-(4-(2-methoxyethoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
1.14.18.1 0.0778
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 5-(4-(4-methoxyethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
1.14.18.1 0.1074
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 5-(4-(2-butoxyethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
1.14.18.1 0.1128
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 5-(4-(2-methoxyethoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
1.14.18.1 0.1325
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 5-(4-(2-(2-methoxyethoxy)ethoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
1.14.18.1 0.1374
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 5-(4-(2-(2-methoxyethoxy)ethoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
1.14.18.1 0.1559
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 5-(4-(2-hydroxyethoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
1.14.18.1 0.1793
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 5-(4-(2-butoxyethoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
1.14.18.1 0.2
-
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 5-(4-(2-hydroxyethoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
1.14.18.1 0.2
-
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 5-(4-(4-methoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
1.14.18.1 0.2
-
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 5-(4-(2-hydroxyethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
1.14.18.1 0.2
-
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 5-(4-hydroxybenzyl)pyrimidine-2,4,6(1H,3H,5H)-trione
1.14.18.1 0.2
-
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 5-(4-(2-hydroxyethoxy)benzyl)pyrimidine-2,4,6(1H,3H,5H)-trione
1.14.18.1 0.2
-
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 5-(4-(2-methoxyethoxy)benzyl)pyrimidine-2,4,6(1H,3H,5H)-trione
1.14.18.1 0.2
-
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 5-(4-(2-(2-methoxyethoxy)ethoxy)benzyl)pyrimidine-2,4,6(1H,3H,5H)trione
1.14.18.1 0.2
-
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 5-(4-(4-methoxyethoxy)benzyl)pyrimidine-2,4,6(1H,3H,5H)-trione
1.14.18.1 0.2
-
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 5-(4-(4-methoxybutoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
1.14.18.1 1.22
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C Agaricus bisporus 4-hydroxybenzaldehyde