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Literature summary extracted from

  • Ozaki, S.; Doi, M.; Migita, C.T.
    Modulation of cystathionine beta-synthase activity by altering heme environment (2008), Chem. Lett., 37, 208-209.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.22 the truncated human CBS enzyme consisting of residue 1-397 is expressed in the glutathione S-transferase fusion expression system Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.2.1.22
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.22 additional information the alternation of heme environment inactivates the enzyme Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.22 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.1.22
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.22 L-serine + L-homocysteine
-
 Homo sapiens L-cystathionine + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
4.2.1.22 homodimer truncated CBS, X-ray crystallography Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
4.2.1.22 CBS
-
 Homo sapiens
4.2.1.22 CBS424 inactive form of CBS Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
4.2.1.22 heme the specific activity of the alkaline form is approximately 25% of that for the intact CBS enzyme when the heme iron is in the ferric state Homo sapiens
4.2.1.22 pyridoxal 5'-phosphate
-
 Homo sapiens