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Literature summary extracted from

  • Kristan, K.; Brunskole, M.; Stojan, J.; Rizner, T.L.
    Two homologous fungal carbonyl reductases with different substrate specificities (2009), Chem. Biol. Interact., 178, 295-302.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.252 expressed as a glutathione S-transferase (GST)-fusion protein in Escherichia coli BL21 cells Curvularia lunata

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.252 3,7-dihydroxyflavone
-
Curvularia lunata
1.1.1.252 3-hydroxyflavone
-
Curvularia lunata
1.1.1.252 5,7-dihydroxyflavone potent inhibitor of 3HNR Curvularia lunata
1.1.1.252 5-hydroxyflavone
-
Curvularia lunata
1.1.1.252 5-methoxyflavone
-
Curvularia lunata
1.1.1.252 5-methyl-(1,2,4)-triazolo[3,4-b]benzothiazole tricyclazole, specific inhibitor of 3HNR Curvularia lunata
1.1.1.252 apigenin potent inhibitor of 3HNR Curvularia lunata
1.1.1.252 Biochanin A
-
Curvularia lunata
1.1.1.252 kaempferol potent inhibitor of 3HNR Curvularia lunata
1.1.1.252 luteolin potent inhibitor of 3HNR Curvularia lunata
1.1.1.252 naringenin
-
Curvularia lunata

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.252 1,3,8-trihydroxynaphthalene + NADPH + H+ Curvularia lunata
-
vermelone + NADP+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.252 Curvularia lunata
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.252 by affinity binding followed by cleavage with thrombin Curvularia lunata

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.252 1,3,8-trihydroxynaphthalene + NADPH + H+
-
Curvularia lunata vermelone + NADP+
-
?
1.1.1.252 1,4-androstadiene-3,17-dione + NADPH + H+ poor substrate of 3HNR Curvularia lunata ? + NADP+
-
?
1.1.1.252 2,(5alpha)-androstene-17-one + NADPH + H+
-
Curvularia lunata ? + NADP+
-
?
1.1.1.252 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one + NADP+
-
Curvularia lunata 4,5-dihydroxy-2H-benzopyran-2-one + NADPH + H+
-
?
1.1.1.252 4-androstene-3,17-dione + NADPH + H+ poor substrate of 3HNR Curvularia lunata ? + NADP+
-
?
1.1.1.252 4-estrene-3,17-dione + NADPH + H+ poor substrate of 3HNR Curvularia lunata ? + NADP+
-
?
1.1.1.252 5-androstene-3beta-ol-17-one + NADPH + H+
-
Curvularia lunata ? + NADP+
-
?
1.1.1.252 5alpha-androstane-3,17-dione + NADPH + H+ best steroid substrate for 3HNR Curvularia lunata ? + NADP+
-
?
1.1.1.252 5alpha-androstane-3-one + NADPH + H+
-
Curvularia lunata ? + NADP+
-
?
1.1.1.252 5alpha-androstane-3alpha-ol-17-one + NADPH + H+
-
Curvularia lunata ? + NADP+
-
?
1.1.1.252 5alpha-androstane-3beta-ol-17-one + NADPH + H+
-
Curvularia lunata ? + NADP+
-
?
1.1.1.252 additional information no activity with estrone Curvularia lunata ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.252 3HNR
-
Curvularia lunata
1.1.1.252 trihydroxynaphthalene reductase
-
Curvularia lunata

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.252 25 30 optimal temperature for oxidation of 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one Curvularia lunata

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.252 8 9 optimal pH for oxidation of 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one Curvularia lunata

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.252 0.0031
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one Curvularia lunata apigenin
1.1.1.252 0.0058
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one Curvularia lunata 5,7-dihydroxyflavone
1.1.1.252 0.0068
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one Curvularia lunata luteolin
1.1.1.252 0.0079
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one Curvularia lunata kaempferol
1.1.1.252 0.012
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one Curvularia lunata Biochanin A
1.1.1.252 0.025
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one Curvularia lunata 3-hydroxyflavone
1.1.1.252 0.025
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one Curvularia lunata 5-hydroxyflavone
1.1.1.252 0.025
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one Curvularia lunata 3,7-dihydroxyflavone
1.1.1.252 0.025
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one Curvularia lunata 5-methoxyflavone
1.1.1.252 0.026
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one Curvularia lunata naringenin