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Literature summary extracted from

  • Cochran, J.C.; Sindelar, C.V.; Mulko, N.K.; Collins, K.A.; Kong, S.E.; Hawley, R.S.; Kull, F.J.
    ATPase cycle of the nonmotile kinesin NOD allows microtubule end tracking and drives chromosome movement (2009), Cell, 136, 110-122.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.6.1.3
-
 Drosophila melanogaster

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
5.6.1.3 catalytic domain in the ADP- and adenosine-5'-(beta,gamma-imido)triphosphate-bound states, hanging drop vapour diffusion method, using 0.1 MES (pH 6.5), 15% polyethylene glycol 20000, at 4°C Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.1.3 additional information Drosophila melanogaster NOD binds tightly to microtubules in the nucleotide-free state, yet other nucleotide states, including adenosine-5'-(beta,gamma-imido)triphosphate, are weakened, NOD interaction with microtubules occurs slowly with weak activation of ADP product release. Upon rapid substrate binding, NOD detaches from the microtubule prior to the rate-limiting step of ATP hydrolysis. ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.3 Drosophila melanogaster
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.6.1.3
-
 Drosophila melanogaster

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.3 ATP + H2O + a kinesin associated with a microtubule at position n
-
 Drosophila melanogaster ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
5.6.1.3 additional information NOD binds tightly to microtubules in the nucleotide-free state, yet other nucleotide states, including adenosine-5'-(beta,gamma-imido)triphosphate, are weakened, NOD interaction with microtubules occurs slowly with weak activation of ADP product release. Upon rapid substrate binding, NOD detaches from the microtubule prior to the rate-limiting step of ATP hydrolysis. Drosophila melanogaster ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.1.3 NOD NOD is a nonmotile kinesin-10 Drosophila melanogaster