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Literature summary extracted from

  • Goldman, A.; Leigh, J.; Samudrala, R.
    Comprehensive computational analysis of Hmd enzymes and paralogs in methanogenic Archaea (2009), BMC Evol. Biol., 9, 199-210.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.12.98.2 Fe Hmd holoenzyme is comprised of 2 iron atoms, each iron atom coordinates the reduction of methenyltetrahydromethanopterin and oxidation of H2 while bound to both Hmd and a cofactor molecule Methanocaldococcus jannaschii

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.12.98.2 38000
-
 the Hmd holoenzyme is comprised of a homodimer of 38 kDa subunits, 2 pyridone derivative cofactor molecules and 2 iron atoms Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.12.98.2 5,10-methenyltetrahydromethanopterin + H2 Methanocaldococcus jannaschii Hmd catalyzes a step in the hydrogenotrophic methanogenesis pathway in class I methanogens 5,10-methylenetetrahydromethanopterin + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.12.98.2 Methanocaldococcus jannaschii Q58194
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.12.98.2 5,10-methenyltetrahydromethanopterin + H2 Hmd catalyzes a step in the hydrogenotrophic methanogenesis pathway in class I methanogens Methanocaldococcus jannaschii 5,10-methylenetetrahydromethanopterin + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.12.98.2 homodimer 2 * 38000, structural modeling of Hmd enzyme reveals a common structural arrangement comprised of one large N-terminal domain containing alpha-helices and beta-sheets and one smaller C-terminal domain containing only alpha-helices Methanocaldococcus jannaschii

Synonyms

EC Number Synonyms Comment Organism
1.12.98.2 H2-forming methylenetetrahydromethanopterin dehydrogenase
-
 Methanocaldococcus jannaschii
1.12.98.2 Hmd
-
 Methanocaldococcus jannaschii

Cofactor

EC Number Cofactor Comment Organism Structure
1.12.98.2 coenzyme F420
-
 Methanocaldococcus jannaschii