Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ng, L.T.; Ko, H.H.; Lu, T.M.
    Potential antioxidants and tyrosinase inhibitors from synthetic polyphenolic deoxybenzoins (2009), Bioorg. Med. Chem., 17, 4360-4366.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 2,3,4'-trihydroxy-4-methoxydeoxybenzoin displays stable and significant inhibitory effect on tyrosinase activity Agaricus bisporus
1.14.18.1 2,3,4,4'-tetrahydroxydeoxybenzoin
-
 Agaricus bisporus
1.14.18.1 2,3,4-trihydroxy-3',4'-dimethoxydeoxybenzoin
-
 Agaricus bisporus
1.14.18.1 2,3,4-trihydroxy-4'-methoxydeoxybenzoin
-
 Agaricus bisporus
1.14.18.1 2,4,4',6-tetrahydroxydeoxybenzoin
-
 Agaricus bisporus
1.14.18.1 2,4,4'-trihydroxydeoxybenzoin
-
 Agaricus bisporus
1.14.18.1 2,4,5-trihydroxy-4'-methoxydeoxybenzoin
-
 Agaricus bisporus
1.14.18.1 2,4,6-trihydroxy-4'-methoxydeoxybenzoin
-
 Agaricus bisporus
1.14.18.1 2,4-dihydroxy-3',4'-dimethoxydeoxybenzoin
-
 Agaricus bisporus
1.14.18.1 2,4-dihydroxy-4'-methoxydeoxybenzoin
-
 Agaricus bisporus
1.14.18.1 3,4-dihydroxy-4'-methoxydeoxybenzoin
-
 Agaricus bisporus
1.14.18.1 kojic acid
-
 Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-tyrosine + L-dopa + O2
-
 Agaricus bisporus L-dopa + dopaquinone + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 tyrosinase
-
 Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.0431
-
 at incubation interval of 1.5 h Agaricus bisporus 2,3,4'-trihydroxy-4-methoxydeoxybenzoin
1.14.18.1 0.04337
-
 at incubation interval of 0.5 h Agaricus bisporus 2,3,4'-trihydroxy-4-methoxydeoxybenzoin
1.14.18.1 0.0461
-
 at incubation interval of 2.5 h Agaricus bisporus 2,3,4'-trihydroxy-4-methoxydeoxybenzoin
1.14.18.1 0.07105
-
 at incubation interval of 0.5 h Agaricus bisporus 2,4,6-trihydroxy-4'-methoxydeoxybenzoin
1.14.18.1 0.0788
-
 at incubation interval of 0.5 h Agaricus bisporus 2,4-dihydroxy-4'-methoxydeoxybenzoin
1.14.18.1 0.08435
-
 at incubation interval of 0.5 h Agaricus bisporus 2,4,5-trihydroxy-4'-methoxydeoxybenzoin
1.14.18.1 0.1121
-
 at incubation interval of 0.5 h Agaricus bisporus 2,4-dihydroxy-3',4'-dimethoxydeoxybenzoin
1.14.18.1 0.1328
-
 at incubation interval of 0.5 h Agaricus bisporus kojic acid
1.14.18.1 0.1359
-
 at incubation interval of 1.5 h Agaricus bisporus 2,4,4'-trihydroxydeoxybenzoin
1.14.18.1 0.1442
-
 at incubation interval of 1.5 h Agaricus bisporus 2,4,5-trihydroxy-4'-methoxydeoxybenzoin
1.14.18.1 0.1604
-
 at incubation interval of 1.5 h Agaricus bisporus 2,4-dihydroxy-4'-methoxydeoxybenzoin
1.14.18.1 0.168
-
 at incubation interval of 1.5 h Agaricus bisporus 3,4-dihydroxy-4'-methoxydeoxybenzoin
1.14.18.1 0.1724
-
 at incubation interval of 2.5 h Agaricus bisporus 2,4,4'-trihydroxydeoxybenzoin
1.14.18.1 0.1777
-
 at incubation interval of 2.5 h Agaricus bisporus 3,4-dihydroxy-4'-methoxydeoxybenzoin
1.14.18.1 0.1785
-
 at incubation interval of 0.5 h Agaricus bisporus 2,4,4'-trihydroxydeoxybenzoin
1.14.18.1 0.1814
-
 at incubation interval of 2.5 h Agaricus bisporus 2,4-dihydroxy-4'-methoxydeoxybenzoin
1.14.18.1 0.1974
-
 at incubation interval of 2.5 h Agaricus bisporus 2,4,5-trihydroxy-4'-methoxydeoxybenzoin
1.14.18.1 0.2033
-
 at incubation interval of 1.5 h Agaricus bisporus 2,3,4-trihydroxy-4'-methoxydeoxybenzoin
1.14.18.1 0.2091
-
 at incubation interval of 1.5 h Agaricus bisporus 2,4-dihydroxy-3',4'-dimethoxydeoxybenzoin
1.14.18.1 0.2119
-
 at incubation interval of 2.5 h Agaricus bisporus 2,3,4-trihydroxy-4'-methoxydeoxybenzoin
1.14.18.1 0.2139
-
 at incubation interval of 1.5 h Agaricus bisporus 2,4,6-trihydroxy-4'-methoxydeoxybenzoin
1.14.18.1 0.2251
-
 at incubation interval of 1.5 h Agaricus bisporus kojic acid
1.14.18.1 0.2302
-
 at incubation interval of 2.5 h Agaricus bisporus 2,4,6-trihydroxy-4'-methoxydeoxybenzoin
1.14.18.1 0.2397
-
 at incubation interval of 2.5 h Agaricus bisporus 2,4-dihydroxy-3',4'-dimethoxydeoxybenzoin
1.14.18.1 0.2613
-
 at incubation interval of 2.5 h Agaricus bisporus 2,4,4',6-tetrahydroxydeoxybenzoin
1.14.18.1 0.3
-
 IC50 above 0.3 mM, at incubation interval of 0.5 h Agaricus bisporus 2,3,4,4'-tetrahydroxydeoxybenzoin
1.14.18.1 0.3
-
 IC50 above 0.3 mM, at incubation interval of 0.5 h Agaricus bisporus 2,3,4-trihydroxy-4'-methoxydeoxybenzoin
1.14.18.1 0.3
-
 IC50 above 0.3 mM, at incubation interval of 0.5 h Agaricus bisporus 3,4-dihydroxy-4'-methoxydeoxybenzoin
1.14.18.1 0.3
-
 IC50 above 0.3 mM, at incubation interval of 0.5 h Agaricus bisporus 2,4,4',6-tetrahydroxydeoxybenzoin
1.14.18.1 0.3
-
 IC50 above 0.3 mM, at incubation interval of 1.5 h Agaricus bisporus 2,3,4,4'-tetrahydroxydeoxybenzoin
1.14.18.1 0.3
-
 IC50 above 0.3 mM, at incubation interval of 1.5 h Agaricus bisporus 2,4,4',6-tetrahydroxydeoxybenzoin
1.14.18.1 0.4383
-
 at incubation interval of 2.5 h Agaricus bisporus kojic acid
1.14.18.1 0.5
-
 IC50 above 0.5 mM, at incubation interval of 2.5 h Agaricus bisporus 2,3,4,4'-tetrahydroxydeoxybenzoin