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Literature summary extracted from

  • Yi, W.; Cao, R.; Wen, H.; Yan, Q.; Zhou, B.; Ma, L.; Song, H.
    Discovery of 4-functionalized phenyl-O-beta-D-glycosides as a new class of mushroom tyrosinase inhibitors (2009), Bioorg. Med. Chem. Lett., 19, 6157-6160.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 1-(propan-2-ylidene)thiosemicarbazide
-
Agaricus bisporus
1.14.18.1 1-[1-(4-methoxyphenyl)ethylidene]thiosemicarbazide
-
Agaricus bisporus
1.14.18.1 3,4-dihydroxybenzaldehyde-O-ethyloxime
-
Agaricus bisporus
1.14.18.1 4-formylphenyl-O-beta-D-allopyranoside
-
Agaricus bisporus
1.14.18.1 4-[(E)-(carbamothioylhydrazono)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-allopyranoside
-
Agaricus bisporus
1.14.18.1 4-[(E)-(carbamothioylhydrazono)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-galactopyranoside
-
Agaricus bisporus
1.14.18.1 4-[(E)-(carbamothioylhydrazono)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside
-
Agaricus bisporus
1.14.18.1 4-[(E)-(carbamothioylhydrazono)methyl]phenyl 2,3,4,6-tetrakis-O-(phenylcarbonyl)-beta-D-glucopyranoside
-
Agaricus bisporus
1.14.18.1 4-[(E)-(carbamothioylhydrazono)methyl]phenyl 2,3,4-tris-O-(phenylcarbonyl)-beta-D-xylopyranoside
-
Agaricus bisporus
1.14.18.1 4-[(E)-(carbamothioylhydrazono)methyl]phenyl 2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-beta-D-glucopyranoside
-
Agaricus bisporus
1.14.18.1 4-[(E)-(carbamothioylhydrazono)methyl]phenyl beta-D-allopyranoside
-
Agaricus bisporus
1.14.18.1 4-[(E)-(carbamothioylhydrazono)methyl]phenyl beta-D-glucopyranoside
-
Agaricus bisporus
1.14.18.1 4-[(E)-(hydroxyimino)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-allopyranoside reversible and competitive-type inhibitor Agaricus bisporus
1.14.18.1 4-[(E)-(hydroxyimino)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-galactopyranoside
-
Agaricus bisporus
1.14.18.1 4-[(E)-(hydroxyimino)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside
-
Agaricus bisporus
1.14.18.1 4-[(E)-(hydroxyimino)methyl]phenyl 2,3,4,6-tetrakis-O-(phenylcarbonyl)-beta-D-glucopyranoside
-
Agaricus bisporus
1.14.18.1 4-[(E)-(hydroxyimino)methyl]phenyl 2,3,4-tris-O-(phenylcarbonyl)-beta-D-xylopyranoside
-
Agaricus bisporus
1.14.18.1 4-[(E)-(hydroxyimino)methyl]phenyl 2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-beta-D-glucopyranoside
-
Agaricus bisporus
1.14.18.1 4-[(E)-(hydroxyimino)methyl]phenyl beta-D-allopyranoside
-
Agaricus bisporus
1.14.18.1 4-[(E)-(hydroxyimino)methyl]phenyl beta-D-glucopyranoside
-
Agaricus bisporus
1.14.18.1 4-[(E)-(methoxyimino)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-allopyranoside
-
Agaricus bisporus
1.14.18.1 4-[(E)-(methoxyimino)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-galactopyranoside
-
Agaricus bisporus
1.14.18.1 4-[(E)-(methoxyimino)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside
-
Agaricus bisporus
1.14.18.1 4-[(E)-(methoxyimino)methyl]phenyl 2,3,4,6-tetrakis-O-(phenylcarbonyl)-beta-D-glucopyranoside
-
Agaricus bisporus
1.14.18.1 4-[(E)-(methoxyimino)methyl]phenyl 2,3,4-tris-O-(phenylcarbonyl)-beta-D-xylopyranoside
-
Agaricus bisporus
1.14.18.1 4-[(E)-(methoxyimino)methyl]phenyl 2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-beta-D-glucopyranoside
-
Agaricus bisporus
1.14.18.1 4-[(E)-(methoxyimino)methyl]phenyl beta-D-allopyranoside
-
Agaricus bisporus
1.14.18.1 4-[(E)-(methoxyimino)methyl]phenyl beta-D-glucopyranoside
-
Agaricus bisporus
1.14.18.1 arbutin
-
Agaricus bisporus
1.14.18.1 tropolone
-
Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-tyrosine + O2
-
Agaricus bisporus L-DOPA + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 cresolase/monophenolase
-
Agaricus bisporus
1.14.18.1 tyrosinase catalyzes two distinct reactions of melanin biosynthesis: the o-hydroxylation of the amino acid L-tyrosine to L-DOPA and subsequently the oxidation of L-DOPA to the corresponding o-dopaquinone Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.000086
-
-
Agaricus bisporus 1-[1-(4-methoxyphenyl)ethylidene]thiosemicarbazide
1.14.18.1 0.00011
-
-
Agaricus bisporus 1-(propan-2-ylidene)thiosemicarbazide
1.14.18.1 0.0003
-
-
Agaricus bisporus 3,4-dihydroxybenzaldehyde-O-ethyloxime
1.14.18.1 0.00031
-
-
Agaricus bisporus 4-[(E)-(carbamothioylhydrazono)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside
1.14.18.1 0.0004
-
-
Agaricus bisporus 2-hydroxytropone
1.14.18.1 0.00041
-
-
Agaricus bisporus 4-[(E)-(carbamothioylhydrazono)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-galactopyranoside
1.14.18.1 0.00065
-
-
Agaricus bisporus 4-[(E)-(carbamothioylhydrazono)methyl]phenyl 2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-beta-D-glucopyranoside
1.14.18.1 0.00296
-
-
Agaricus bisporus 4-[(E)-(carbamothioylhydrazono)methyl]phenyl beta-D-glucopyranoside
1.14.18.1 0.00341
-
-
Agaricus bisporus 4-[(E)-(carbamothioylhydrazono)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-allopyranoside
1.14.18.1 0.00361
-
-
Agaricus bisporus 4-[(E)-(carbamothioylhydrazono)methyl]phenyl beta-D-allopyranoside
1.14.18.1 0.0365
-
-
Agaricus bisporus 4-[(E)-(carbamothioylhydrazono)methyl]phenyl 2,3,4-tris-O-(phenylcarbonyl)-beta-D-xylopyranoside
1.14.18.1 0.0528
-
-
Agaricus bisporus 4-[(E)-(carbamothioylhydrazono)methyl]phenyl 2,3,4,6-tetrakis-O-(phenylcarbonyl)-beta-D-glucopyranoside
1.14.18.1 0.2
-
IC50 above 0.2 mM Agaricus bisporus 4-[(E)-(hydroxyimino)methyl]phenyl beta-D-allopyranoside
1.14.18.1 0.2
-
IC50 above 0.2 mM Agaricus bisporus 4-[(E)-(hydroxyimino)methyl]phenyl beta-D-glucopyranoside
1.14.18.1 0.2
-
IC50 above 0.2 mM Agaricus bisporus 4-[(E)-(hydroxyimino)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-allopyranoside
1.14.18.1 0.2
-
IC50 above 0.2 mM Agaricus bisporus 4-[(E)-(hydroxyimino)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside
1.14.18.1 0.2
-
IC50 above 0.2 mM Agaricus bisporus 4-[(E)-(hydroxyimino)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-galactopyranoside
1.14.18.1 0.2
-
IC50 above 0.2 mM Agaricus bisporus 4-[(E)-(hydroxyimino)methyl]phenyl 2,3,4,6-tetrakis-O-(phenylcarbonyl)-beta-D-glucopyranoside
1.14.18.1 0.2
-
IC50 above 0.2 mM Agaricus bisporus 4-[(E)-(hydroxyimino)methyl]phenyl 2,3,4-tris-O-(phenylcarbonyl)-beta-D-xylopyranoside
1.14.18.1 0.2
-
IC50 above 0.2 mM Agaricus bisporus 4-[(E)-(hydroxyimino)methyl]phenyl 2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-beta-D-glucopyranoside
1.14.18.1 0.2
-
IC50 above 0.2 mM Agaricus bisporus 4-[(E)-(methoxyimino)methyl]phenyl beta-D-allopyranoside
1.14.18.1 0.2
-
IC50 above 0.2 mM Agaricus bisporus 4-[(E)-(methoxyimino)methyl]phenyl beta-D-glucopyranoside
1.14.18.1 0.2
-
IC50 above 0.2 mM Agaricus bisporus 4-[(E)-(methoxyimino)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-allopyranoside
1.14.18.1 0.2
-
IC50 above 0.2 mM Agaricus bisporus 4-[(E)-(methoxyimino)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside
1.14.18.1 0.2
-
IC50 above 0.2 mM Agaricus bisporus 4-[(E)-(methoxyimino)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-galactopyranoside
1.14.18.1 0.2
-
IC50 above 0.2 mM Agaricus bisporus 4-[(E)-(methoxyimino)methyl]phenyl 2,3,4,6-tetrakis-O-(phenylcarbonyl)-beta-D-glucopyranoside
1.14.18.1 0.2
-
IC50 above 0.2 mM Agaricus bisporus 4-[(E)-(methoxyimino)methyl]phenyl 2,3,4-tris-O-(phenylcarbonyl)-beta-D-xylopyranoside
1.14.18.1 0.2
-
IC50 above 0.2 mM Agaricus bisporus 4-[(E)-(methoxyimino)methyl]phenyl 2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-beta-D-glucopyranoside
1.14.18.1 2.54
-
-
Agaricus bisporus 4-formylphenyl-O-beta-D-allopyranoside
1.14.18.1 7.3
-
-
Agaricus bisporus arbutin