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Literature summary extracted from

  • Kang, S.S.; Kim, H.J.; Jin, C.; Lee, Y.S.
    Synthesis of tyrosinase inhibitory (4-oxo-4H-pyran-2-yl)acrylic acid ester derivatives (2009), Bioorg. Med. Chem. Lett., 19, 188-191.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 1-methylethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
-
Agaricus bisporus
1.14.18.1 2-(2-hydroxyethoxy)ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
-
Agaricus bisporus
1.14.18.1 2-(2-methoxyethoxy)ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
-
Agaricus bisporus
1.14.18.1 2-hydroxyethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
-
Agaricus bisporus
1.14.18.1 2-methoxyethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
-
Agaricus bisporus
1.14.18.1 2-[2-(2-hydroxyethoxy)ethoxy]ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
-
Agaricus bisporus
1.14.18.1 2-[2-(2-methoxyethoxy)ethoxy]ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
-
Agaricus bisporus
1.14.18.1 caffeic acid
-
Agaricus bisporus
1.14.18.1 ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
-
Agaricus bisporus
1.14.18.1 kojic acid
-
Agaricus bisporus
1.14.18.1 octyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
-
Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-tyrosine + O2
-
Agaricus bisporus L-DOPA + H2O
-
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Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 tyrosinase
-
Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.0265
-
in 0.1 M phosphate buffer (pH 6.8), at 37°C Agaricus bisporus 2-(2-hydroxyethoxy)ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
1.14.18.1 0.0363
-
in 0.1 M phosphate buffer (pH 6.8), at 37°C Agaricus bisporus ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
1.14.18.1 0.0591
-
in 0.1 M phosphate buffer (pH 6.8), at 37°C Agaricus bisporus 2-(2-methoxyethoxy)ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
1.14.18.1 0.0676
-
in 0.1 M phosphate buffer (pH 6.8), at 37°C Agaricus bisporus 2-[2-(2-methoxyethoxy)ethoxy]ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
1.14.18.1 0.0749
-
in 0.1 M phosphate buffer (pH 6.8), at 37°C Agaricus bisporus 2-hydroxyethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
1.14.18.1 0.0792
-
in 0.1 M phosphate buffer (pH 6.8), at 37°C Agaricus bisporus 2-[2-(2-hydroxyethoxy)ethoxy]ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
1.14.18.1 0.0803
-
in 0.1 M phosphate buffer (pH 6.8), at 37°C Agaricus bisporus 1-methylethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
1.14.18.1 0.0981
-
in 0.1 M phosphate buffer (pH 6.8), at 37°C Agaricus bisporus 2-methoxyethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
1.14.18.1 0.323
-
in 0.1 M phosphate buffer (pH 6.8), at 37°C Agaricus bisporus kojic acid
1.14.18.1 0.4
-
in 0.1 M phosphate buffer (pH 6.8), at 37°C Agaricus bisporus octyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate