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Literature summary extracted from

  • Innocenti, A.; Hilvo, M.; Scozzafava, A.; Parkkila, S.; Supuran, C.T.
    Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols (2008), Bioorg. Med. Chem. Lett., 18, 3593-3596.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.1 2,5-difluorophenol
-
 Mus musculus
4.2.1.1 3,5-difluorophenol
-
 Mus musculus
4.2.1.1 4-Aminophenol
-
 Mus musculus
4.2.1.1 4-hydroxybenzoic acid
-
 Mus musculus
4.2.1.1 4-Hydroxybenzonitrile
-
 Mus musculus
4.2.1.1 acetazolamide
-
 Mus musculus
4.2.1.1 benzene-1,2-diol
-
 Mus musculus
4.2.1.1 benzene-1,3-diol
-
 Mus musculus
4.2.1.1 benzene-1,4-diol
-
 Mus musculus
4.2.1.1 clioquinol
-
 Mus musculus
4.2.1.1 paracetamol
-
 Mus musculus
4.2.1.1 phenol
-
 Mus musculus
4.2.1.1 salicylic acid
-
 Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.1.1 14.2
-
 CO2 at pH 7.5 and 20°C Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.1 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.1 CO2 + H2O
-
 Mus musculus H2CO3
-
 r

Synonyms

EC Number Synonyms Comment Organism
4.2.1.1 Ca XV
-
 Mus musculus
4.2.1.1 carbonic anhydrase XV isoform Mus musculus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2.1.1 470000
-
 CO2 at pH 7.5 and 20°C Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.1.1 0.000072
-
 acetazolamide at pH 7.5 and 20°C Mus musculus
4.2.1.1 0.00233
-
 clioquinol at pH 7.5 and 20°C Mus musculus
4.2.1.1 0.0072
-
 salicylic acid at pH 7.5 and 20°C Mus musculus
4.2.1.1 0.00923
-
 paracetamol at pH 7.5 and 20°C Mus musculus
4.2.1.1 0.00932
-
 4-hydroxybenzoic acid at pH 7.5 and 20°C Mus musculus
4.2.1.1 0.0102
-
 benzene-1,2-diol at pH 7.5 and 20°C Mus musculus
4.2.1.1 0.0105
-
 phenol at pH 7.5 and 20°C Mus musculus
4.2.1.1 0.0106
-
 benzene-1,4-diol at pH 7.5 and 20°C Mus musculus
4.2.1.1 0.0113
-
 3,5-difluorophenol at pH 7.5 and 20°C Mus musculus
4.2.1.1 0.212
-
 2,5-difluorophenol at pH 7.5 and 20°C Mus musculus
4.2.1.1 0.335
-
 4-Aminophenol at pH 7.5 and 20°C Mus musculus
4.2.1.1 0.385
-
 benzene-1,3-diol at pH 7.5 and 20°C Mus musculus
4.2.1.1 0.434
-
 4-Hydroxybenzonitrile at pH 7.5 and 20°C Mus musculus