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Literature summary extracted from

  • Sentuerk, M.; Guelcin, I.; Ciftci, M.; Kuefrevioglu, O.I.
    Dantrolene inhibits human erythrocyte glutathione reductase (2008), Biol. Pharm. Bull., 31, 2036-2039.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.7 dantrolene non-competitive inhibition Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.7 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.1.7 ammonium sulfate precipitation, 2 ',5'-ADP Sepharose-4B affinity column chromatography and Sephadex G-200 gel filtration Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.7 erythrocyte
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.8.1.7 0.009
-
hemolysate, at 25°C, pH 8.0 Homo sapiens
1.8.1.7 23
-
2555fold purified enzyme, at 25°C, pH 8.0 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.7 glutathione disulfide + NADPH + H+
-
Homo sapiens glutathione + NADP+
-
r

Synonyms

EC Number Synonyms Comment Organism
1.8.1.7 glutathione reductase
-
Homo sapiens
1.8.1.7 glutathione: NADP+ oxidoreductase
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.7 FAD
-
Homo sapiens
1.8.1.7 NADPH
-
Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.8.1.7 0.1116
-
dantrolene at 25°C, pH 8.0 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.8.1.7 0.0523
-
at 25°C, pH 8.0 Homo sapiens dantrolene