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Literature summary extracted from

  • Lee, E.H.; Song, D.G.; Lee, J.Y.; Pan, C.H.; Um, B.H.; Jung, S.H.
    Inhibitory effect of the compounds isolated from Rhus verniciflua on aldose reductase and advanced glycation endproducts (2008), Biol. Pharm. Bull., 31, 1626-1630.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.21 expressed in Escherichia coli BL21 (DE3) cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 butein 89.9% inhibition at 0.002 mM Homo sapiens
1.1.1.21 epalrestat 85.8% inhibition at 0.0025 mM Homo sapiens
1.1.1.21 fisetin 31.1% inhibition at 0.002 mM Homo sapiens
1.1.1.21 fustin 20.1% inhibition at 0.002 mM Homo sapiens
1.1.1.21 Morin hydrate 14.1% inhibition at 0.002 mM Homo sapiens
1.1.1.21 pentagalloyl glucose 46.6% inhibition at 0.002 mM Homo sapiens
1.1.1.21 protocatechuic acid 12.6% inhibition at 0.002 mM Homo sapiens
1.1.1.21 quercetin 39.1% inhibition at 0.002 mM Homo sapiens
1.1.1.21 sulfuretin 69.8% inhibition at 0.002 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.21 Ni-NTA resin column chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.21 DL-glyceraldehyde + NADPH + H+
-
 Homo sapiens glycerol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.21 alditol/NADP+ oxidoreductase
-
 Homo sapiens
1.1.1.21 aldose reductase
-
 Homo sapiens
1.1.1.21 ALR2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.21 NADPH
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.21 0.0007
-
 in 0.1 M sodium phosphate buffer (pH 6.2) Homo sapiens butein
1.1.1.21 0.0013
-
 in 0.1 M sodium phosphate buffer (pH 6.2) Homo sapiens epalrestat
1.1.1.21 0.0013
-
 in 0.1 M sodium phosphate buffer (pH 6.2) Homo sapiens sulfuretin