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Literature summary extracted from

  • Banerjee, T.; Sharma, S.K.; Surolia, N.; Surolia, A.
    Epigallocatechin gallate is a slow-tight binding inhibitor of enoyl-ACP reductase from Plasmodium falciparum (2008), Biochem. Biophys. Res. Commun., 377, 1238-1242.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.3.1.9 medicine epigallocatechin gallate is a promising candidate for the development of tea catechin based antimalarial drugs Plasmodium falciparum

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.9
-
 Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.9 epigallocatechin gallate
-
 Plasmodium falciparum
1.3.1.9 triclosan triclosan lowers the Ki of epigallocatechin gallate Plasmodium falciparum

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.9 Plasmodium falciparum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.9
-
 Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.9 crotonyl-CoA + NAD+ activity assay Plasmodium falciparum butyryl-CoA + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.9 enoyl-ACP reductase
-
 Plasmodium falciparum
1.3.1.9 ENR
-
 Plasmodium falciparum
1.3.1.9 FabI
-
 Plasmodium falciparum
1.3.1.9 pfENR
-
 Plasmodium falciparum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.9 7.5
-
 activity assay Plasmodium falciparum

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.9 NAD+
-
 Plasmodium falciparum

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.1.9 0.0000106
-
 epigallocatechin gallate epigallocatechin gallate with triclosan Plasmodium falciparum
1.3.1.9 0.000084
-
 epigallocatechin gallate
-
 Plasmodium falciparum