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Literature summary extracted from

  • Hotter, G.S.; Mouat, P.; Collins, D.M.
    Independent transcription of glutamine synthetase (glnA2) and glutamine synthetase adenylyltransferase (glnE) in Mycobacterium bovis and Mycobacterium tuberculosis (2008), Tuberculosis, 88, 382-389.
    View publication on PubMed

Application

EC Number Application Comment Organism
6.3.1.2 medicine glutamine synthetase is a target for disruption in the development of vaccines against both bovine and human tuberculosis. Glutamine synthetase is also a potential target for tuberculosis chemotherapy Mycobacterium tuberculosis variant bovis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.1.2 gene glnA1, genetic organization of glnA1 and glnE, RT-PCR expression analysis, overview Mycobacterium tuberculosis
6.3.1.2 gene glnA1, genetic organization of glnA1 and glnE, RT-PCR expression analysis, overview Mycobacterium tuberculosis variant bovis
6.3.1.2 gene glnA2, DNA and amino acid sequence determination and analysis of glnA2, genetic organization of glnA2 and glnE, chromosomal structure of the glnA2/glnE locus, RT-PCR expression analysis, overview Mycobacterium tuberculosis
6.3.1.2 gene glnA2, DNA and amino acid sequence determination and analysis of glnA2, genetic organization of glnA2 and glnE, chromosomal structure of the glnA2/glnE locus, RT-PCR expression analysis, overview Mycobacterium tuberculosis variant bovis

Protein Variants

EC Number Protein Variants Comment Organism
6.3.1.2 additional information a glnA2 mutant provides protection against infection with virulent Mycobacterium bovis Mycobacterium tuberculosis variant bovis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.1.2 Mg2+
-
 Mycobacterium tuberculosis
6.3.1.2 Mg2+
-
 Mycobacterium tuberculosis variant bovis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.1.2 ATP + L-glutamate + NH3 Mycobacterium tuberculosis
-
 ADP + phosphate + L-glutamine
-
 ?
6.3.1.2 ATP + L-glutamate + NH3 Mycobacterium tuberculosis variant bovis
-
 ADP + phosphate + L-glutamine
-
 ?
6.3.1.2 ATP + L-glutamate + NH3 Mycobacterium tuberculosis H37Rv
-
 ADP + phosphate + L-glutamine
-
 ?
6.3.1.2 ATP + L-glutamate + NH3 Mycobacterium tuberculosis variant bovis AF2122/97
-
 ADP + phosphate + L-glutamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.42 Mycobacterium tuberculosis
-
-
-
2.7.7.42 Mycobacterium tuberculosis H37Rv
-
-
-
2.7.7.42 Mycobacterium tuberculosis variant bovis
-
-
-
2.7.7.42 Mycobacterium tuberculosis variant bovis AF2122/97
-
-
-
6.3.1.2 Mycobacterium tuberculosis P9WN39 gene glnA2
-
6.3.1.2 Mycobacterium tuberculosis P9WN39 gene glnA1
-
6.3.1.2 Mycobacterium tuberculosis H37Rv P9WN39 gene glnA2
-
6.3.1.2 Mycobacterium tuberculosis H37Rv P9WN39 gene glnA1
-
6.3.1.2 Mycobacterium tuberculosis variant bovis P0A591 gene glnA1
-
6.3.1.2 Mycobacterium tuberculosis variant bovis P64246 gene glnA
-
6.3.1.2 Mycobacterium tuberculosis variant bovis AF2122/97 P0A591 gene glnA1
-
6.3.1.2 Mycobacterium tuberculosis variant bovis AF2122/97 P64246 gene glnA
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.42 ATP + [L-glutamate:ammonia ligase (ADP-forming)]
-
 Mycobacterium tuberculosis diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)
-
 ?
2.7.7.42 ATP + [L-glutamate:ammonia ligase (ADP-forming)]
-
 Mycobacterium tuberculosis variant bovis diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)
-
 ?
2.7.7.42 ATP + [L-glutamate:ammonia ligase (ADP-forming)]
-
 Mycobacterium tuberculosis H37Rv diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)
-
 ?
2.7.7.42 ATP + [L-glutamate:ammonia ligase (ADP-forming)]
-
 Mycobacterium tuberculosis variant bovis AF2122/97 diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)
-
 ?
6.3.1.2 ATP + L-glutamate + NH3
-
 Mycobacterium tuberculosis ADP + phosphate + L-glutamine
-
 ?
6.3.1.2 ATP + L-glutamate + NH3
-
 Mycobacterium tuberculosis variant bovis ADP + phosphate + L-glutamine
-
 ?
6.3.1.2 ATP + L-glutamate + NH3
-
 Mycobacterium tuberculosis H37Rv ADP + phosphate + L-glutamine
-
 ?
6.3.1.2 ATP + L-glutamate + NH3
-
 Mycobacterium tuberculosis variant bovis AF2122/97 ADP + phosphate + L-glutamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.42 glutamine synthetase adenylyltransferase
-
 Mycobacterium tuberculosis
2.7.7.42 glutamine synthetase adenylyltransferase
-
 Mycobacterium tuberculosis variant bovis

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.7.42 ATP
-
 Mycobacterium tuberculosis
2.7.7.42 ATP
-
 Mycobacterium tuberculosis variant bovis
6.3.1.2 ATP
-
 Mycobacterium tuberculosis
6.3.1.2 ATP
-
 Mycobacterium tuberculosis variant bovis